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Histological findings in unclassified sudden infant death, including sudden infant death syndrome.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Liebrechts-Akkerman, Germaine Bovée, Judith V. M. G. Wijnaendts, Liliane C. D. Maes, Ann Nikkels, Peter G. J. de Krijger, Ronald R.
Description	Country affiliation: Netherlands Author Affiliation: Liebrechts-Akkerman G ( Department of Pathology, Erasmus MC-University Medical Center, Rotterdam, The Netherlands. g.akkerman@erasmusmc.nl)
Abstract	Our objective was to study histological variations and abnormalities in unclassified sudden infant death (USID), including sudden infant death syndrome (SIDS), in The Netherlands. Two hundred Dutch USID cases between 1984 and 2005 were identified. The histology slides and autopsy reports of 187 cases were available for systematic review, including brain autopsy in 135 cases. An explanation for the cause of death in 19 patients (10.2%) was found. Twelve patients had bronchopneumonia, 3 showed extensive aspiration, 2 had signs of a metabolic disorder, 1 had sepsis, and 1 had meningitis. Frequent nonspecific findings were congestion (66%), edema (47%), small hemorrhages (18%), and lymphoid aggregates (51%) in the lungs; congestion of the liver (23%); and asphyctic bleeding in the kidney (44%), adrenal gland (23%), and thymus (17%). Statistical associations were found for infection with starry sky macrophages in the thymus (P â =â 0.004), with calcification (P â =â 0.023), or with debris in the Hassal's corpuscles (P â =â 0.034). In this study, in 10.2% of cases the histological findings were incompatible with SIDS or USID. Furthermore, several frequent nonspecific histological findings in the thymus that point toward an infection were found.
File Format	HTM / HTML
ISSN	10935266
Issue Number	3
Journal	Pediatric and Developmental Pathology
Volume Number	16
e-ISSN	16155742
Language	English
Publisher	Sage Publication
Publisher Date	2013-05-01
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Pathology Discipline Pediatrics Sudden Infant Death Etiology Pathology Humans Infant Infant, Newborn Retrospective Studies Epidemiology Journal Article
Content Type	Text
Resource Type	Article
Subject	Pathology and Forensic Medicine Pediatrics, Perinatology and Child Health

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