NDLI: Temporal Macular Atrophy as a Predictor of Neovascularization in Sickle Cell Retinopathy.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Hood, Michael P. Diaz, Rocio I. Sigler, Eric J. Calzada, Jorge I.
Abstract	BACKGROUND AND OBJECTIVE: To evaluate the association between temporal macular atrophy and the presence of neovascularization in eyes with sickle cell disease (SCD). PATIENTS AND METHODS: Retrospective, case-controlled study identifying 64 eyes from 38 consecutive patients with SCD. Dilated funduscopic examination and wide-field fluorescein angiography were used to identify the Goldberg stage of proliferative sickle cell retinopathy. Spectral-domain optical coherence tomography images were analyzed for the presence of temporal macular atrophy. The association between temporal macular atrophy and neovascularization was then evaluated. RESULTS: Temporal macular atrophy had a sensitivity of 27%, a specificity of 67%, a positive predictive value of 83%, and a negative predictive value of 13% for identifying neovascularization. CONCLUSION: Although the presence of temporal macular atrophy is not sensitive enough to be used as a screening test, if seen in a patient with SCD, the physician should be alerted to the strong possibility that peripheral neovascularization may be present.
File Format	HTM / HTML
ISSN	23258160
Issue Number	1
Volume Number	47
e-ISSN	23258179
Journal	Ophthalmic Surgery, Lasers and Imaging Retina
Language	English
Publisher	Healio
Publisher Date	2016-01-01
Publisher Place	United States
Access Restriction	Subscribed
Subject Keyword	Discipline Ophthalmology Discipline Surgery Anemia, Sickle Cell Diagnosis Macula Lutea Pathology Retinal Neovascularization Adolescent Adult Aged Atrophy Case-control Studies False Positive Reactions Female Humans Male Middle Aged Predictive Value Of Tests Retrospective Studies Sensitivity And Specificity Tomography, Optical Coherence Young Adult Journal Article
Content Type	Text
Resource Type	Article
Subject	Ophthalmology Surgery

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