NDLI: Phytochemical analysis and evaluation of antioxidant activities of methanolic extracts of Maytenus emarginata.

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Phytochemical analysis and evaluation of antioxidant activities of methanolic extracts of Maytenus emarginata.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Gupta, Vandana Sharma, Mukta
Description	Country affiliation: India Author Affiliation: Gupta V ( Department of Biotechnology, Uttarakhand Technical University, Dehradun, India. vandanag29@gmail.com)
Abstract	Reactive oxygen species (ROS) is a metabolic side product of oxidative stress process, which causes several diseases like atherosclerosis, cancer, etc. In defense of ROS, antioxidants play a key role in combating them. As the process of aging increases, the level of antioxidants in our body decreases and thereby needs utmost attention for its repair process, which is generally administered externally. Plant products serve a best source for controlling these activities by its own metabolic pathway. Studies on the antioxidant activities of Maytenus emarginata leaf extracts are lacking. Antioxidant activity of the methanol extract of Maytenus emarginata was determined by DPPH free radical nitric oxide scavenging assays, superoxide ion scavenging assays, ABTS, and iron chelating methods. Preliminary phytochemical screening revealed that the extract of Maytenus emarginata leaves possesses phenols, flavonoids, steroids, glycosides, saponins, tannins, and triterpenoids. The extract showed significant activities in all antioxidant assays compared to the standard antioxidant (ascorbic acid) in a dose-dependent manner, and remarkable activities to scavenge ROS may be attributed by the presence of the above active compounds in the leaves. The amount of total phenolics and flavonoid contents were also estimated. The DPPH, ABTS, Nitric oxide, superoxide, and iron chelating IC(50) values of the methanolic extracts were 12.44, 24.27, 22.41, 5.85, and 2.74 µg/mL, respectively. The total phenolic content of the methanolic extract was 10.69 mg CA/g, whereas the total flavonoid was 1.56 mg CAE/g. The antioxidant activities were correlated with the total phenolic content. This result suggests that the relatively high antioxidant activity of the methanolic extract compared to standard could be possibly be due to its high phenolic content.
File Format	HTM / HTML
ISSN	15362310
Issue Number	5
Volume Number	16
e-ISSN	15578100
Journal	OMICS: A Journal of Integrative Biology
Language	English
Publisher	Mary Ann Liebert, Inc.
Publisher Date	2012-05-01
Publisher Place	United States
Access Restriction	Subscribed
Subject Keyword	Discipline Molecular Biology Discipline Computational Biology Antioxidants Chemistry Pharmacology Maytenus Plant Extracts Alkaloids Benzothiazoles Biphenyl Compounds Flavonoids Free Radical Scavengers Iron Chelating Agents Nitric Oxide Picrates Plant Leaves Reactive Oxygen Species Saponins Sulfonic Acids Superoxides Tannins Thiazoles Journal Article
Content Type	Text
Resource Type	Article
Subject	Genetics Medicine Molecular Biology Biochemistry Molecular Medicine Biotechnology

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