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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Oh, Chang Hyun Kim, Eunae Hong, Joon Hee |
| Description | Author Affiliation: Oh CH ( Biomaterials Center, Korea Institute of Science and Technology, Seoul, Republic of Korea.) |
| Abstract | The discovery of 2'-spirocyclopropyl-ribocytidine as a potent inhibitor of RNA synthesis by NS5B (IC(50) = 7.3 µM), the RNA polymerase encoded by hepatitis C virus (HCV), has led to the synthesis and biological evaluation of carbocyclic versions of 2'-spiropropyl-nucleosides from cyclopentenol 6. Spirocyclopropylation of enone 7 was completed by using (2-chloroethyl)-dimethylsulfonium iodide and potassium t-butoxide to form the desired intermediate 9a. The synthesized nucleoside analogues, 18, 19, 26, and 27, were assayed for their ability to inhibit HCV RNA replication in a subgenomic replicon Huh7 cell line. The synthesized cytosine nucleoside 19 showed moderate anti-HCV activity (IC(50) = 14.4 µM). |
| File Format | HTM / HTML |
| ISSN | 15257770 |
| Issue Number | 6 |
| Volume Number | 30 |
| e-ISSN | 15322335 |
| Journal | Nucleosides, Nucleotides and Nucleic Acids |
| Language | English |
| Publisher | Taylor & Francis |
| Publisher Date | 2011-06-01 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Biochemistry Antiviral Agents Chemistry Pharmacology Hepacivirus Drug Effects Hepatitis C Drug Therapy Ribonucleosides Chemical Synthesis Cell Line Drug Design Humans Rna, Viral Spiro Compounds Virus Replication Journal Article |
| Content Type | Text |
| Resource Type | Article |
| Subject | Genetics Medicine Biochemistry Molecular Medicine |
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