NDLI: Natural product-derived pharmacological modulators of Nrf2/ARE pathway for chronic diseases.

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Natural product-derived pharmacological modulators of Nrf2/ARE pathway for chronic diseases.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Kumar, Hemant Kim, In-Su More, Sandeep Vasant Kim, Byung-Wook Choi, Dong-Kug
Description	Author Affiliation: Kumar H ( Department of Biotechnology, College of Biomedical and Health Science, Konkuk University, 380-701, Korea. choidk@kku.ac.kr.)
Abstract	Covering: 2000 to 2013. Oxidative stress is the central component of chronic diseases. The nuclear factor erythroid 2-related factor 2/antioxidant response element (Nrf2/ARE) pathway is vital in the up-regulation of cytoprotective genes and enzymes in response to oxidative stress and treatment with certain dietary phytochemicals. Herein, we classify bioactive compounds derived from natural products that are Nrf2/ARE pathway activators and recapitulate the molecular mechanisms for inducing Nrf2 to provide favorable effects in experimental models of chronic diseases. Moreover, pharmacological inhibition of Nrf2 signalling has emerged as promising strategy against multi-drug resistance thereby improving the treatment efficacy. We have also enlisted natural product-derived inhibitors of Nrf2/ARE pathway.
File Format	HTM / HTML
ISSN	02650568
Issue Number	1
Volume Number	31
e-ISSN	14604752
Journal	Natural Product Reports
Language	English
Publisher	Royal Society of Chemistry
Publisher Date	2014-01-01
Publisher Place	Great Britain (UK)
Access Restriction	Subscribed
Subject Keyword	Discipline Chemistry Antioxidants Therapeutic Use Biological Products Chronic Disease Drug Therapy Nf-e2-related Factor 2 Animals Chemistry Humans Mice Mice, Knockout Molecular Structure Genetics Metabolism Physiology Oxidative Stress Drug Effects Rats Journal Article Research Support, Non-u.s. Gov't Review
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Drug Discovery Biochemistry

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