NDLI: Chemo- and site-selective derivatizations of natural products enabling biological studies.

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Chemo- and site-selective derivatizations of natural products enabling biological studies.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Robles, Omar Romo, Daniel
Description	Country affiliation: United States Author Affiliation: Robles O ( Department of Chemistry, Texas A&M University, College Station, Texas 77842-3012, USA. romo@tamu.edu.)
Abstract	Bioactive natural products and derivatives remain an enduring starting point for the discovery of new cellular targets for disease intervention and lead compounds for the development of new therapeutic agents. The former goal is accomplished through the synthesis of bioactive cellular probes from natural products, enabling insights into the mechanism of action of these natural products by classical affinity chromatography or more recent proteome profiling methods. However, the direct and selective modification of native natural products for these purposes remains a challenge due to the structural complexity and the wide functional group diversity found in these natural substances. The lack of selective synthetic methods available to directly manipulate unprotected complex small molecules, in particular to perform structure-activity relationship studies and prepare appropriate cellular probes, has recently begun to be addressed, benefitting from the broader emerging area of chemoselective synthetic methodology. Thus, new reagents, catalysts and reaction processes are enabling both chemo- and site-selective modifications of complex, native natural products. In this review, we describe selected recent examples of these functionalization strategies in this emerging area.
File Format	HTM / HTML
ISSN	02650568
e-ISSN	14604752
DOI	10.1039/c3np70087a
Journal	Natural Product Reports
Issue Number	3
Volume Number	31
Language	English
Publisher	Royal Society of Chemistry
Publisher Date	2014-03-01
Publisher Place	Great Britain (UK)
Access Restriction	Open
Subject Keyword	Discipline Chemistry Biological Products Chemical Synthesis Chemistry Pharmacology Drug Discovery Molecular Structure Structure-activity Relationship Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Drug Discovery Biochemistry

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