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On the industrial applications of MCRs: molecular diversity in drug discovery and generic drug synthesis.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Kalinski, Cédric Umkehrer, Michael Weber, Lutz Kolb, Jürgen Burdack, Christoph Ross, Günther
Description	Country affiliation: Germany Author Affiliation: Kalinski C ( Priaxon AG, Gmunder Straße 37-37a, 81379, Munich, Germany. kalinski@priaxon.com)
Abstract	During the last decades, multicomponent chemistry has gained much attention in pharmaceutical research, especially in the context of lead finding and optimization. Here, in particular, the main advantages of multicomponent reactions (MCRs) like ease of automation and high diversity generation were utilized. In consequence of these beneficial properties, a plethora of new MCRs combined with appropriate classical reaction sequences have been published, the accessible chemical space was extended steadily. In the meantime, the desired high diversity became a challenge itself, because by now the systematic use of this huge and unmanageable space for drug discovery was limited by the lack of suitable computational tools. Therefore, this article provides an insight for the rational use of this enormous chemical space in drug discovery and generic drug synthesis. In this context, a short overview of the applied chemo informatics, necessary for the virtual screening of the biggest available chemical space, is given. Furthermore, some examples for recently developed multicomponent sequences are presented.
File Format	HTM / HTML
ISSN	13811991
Issue Number	3
Volume Number	14
e-ISSN	1573501X
Journal	Molecular Diversity
Language	English
Publisher	Springer
Publisher Date	2010-08-01
Publisher Place	Netherlands
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Molecular Biology Chemical Industry Methods Chemistry, Organic Drug Discovery Drugs, Generic Chemistry Chemical Synthesis Computational Biology Drug Evaluation, Preclinical Journal Article Review
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Medicine Drug Discovery Molecular Biology Physical and Theoretical Chemistry Information Systems Catalysis Inorganic Chemistry

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