NDLI: Role of herpes simplex virus 1 Us3 in viral neuroinvasiveness.

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Role of herpes simplex virus 1 Us3 in viral neuroinvasiveness.

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Role of herpes simplex virus 1 Us3 in viral neuroinvasiveness.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Koyanagi, Naoto Imai, Takahiko Arii, Jun Kato, Akihisa Kawaguchi, Yasushi
Description	Country affiliation: Japan Author Affiliation: Koyanagi N ( Division of Molecular Virology, Department of Microbiology and Immunology)
Abstract	Us3 is a serine-threonine protein kinase that is encoded by herpes simplex virus 1 (HSV-1). In experimental animal models of HSV infection, peripheral and intracranial inoculations can be used to study viral pathogenicity in peripheral sites (e.g., eyes and vagina) and central nervous systems (CNSs), respectively. In addition, peripheral inoculation can be used to investigate this virus' ability to invade the CNS (neuroinvasiveness) from peripheral sites. HSV-1 Us3 has previously been shown to be critical for viral pathogenicity in both peripheral sites and CNSs of mice. However, the role of HSV-1 Us3 in viral neuroinvasiveness has not yet been elucidated. In the present study, the yields of a Us3 null mutant virus and its repaired virus in the eyes, trigeminal ganglia, and brains of mice following ocular inoculation were examined. It was found that, although the repaired virus appeared in the brains of mice 3 days after infection, peak replication occurring 7 days after infection, no viral replication of the Us3 null mutant virus was detectable. These findings indicate that HSV-1 Us3 plays a crucial role in the ability of the virus to invade the brain from the eyes. Thus, HSV-1 Us3 is a significant neuroinvasiveness factor in vivo.
File Format	HTM / HTML
ISSN	03855600
Issue Number	1
Volume Number	58
e-ISSN	13480421
Journal	Microbiology and Immunology
Language	English
Publisher	Wiley-Blackwell
Publisher Date	2014-01-01
Publisher Place	Australia
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Microbiology Discipline Immunology Herpesvirus 1, Human Physiology Pathogenicity Protein-serine-threonine Kinases Metabolism Viral Proteins Animals Brain Pathology Virology Eye Female Gene Order Genome, Viral Herpes Simplex Humans Mice Genetics Trigeminal Ganglion Virus Replication Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Virology Immunology Microbiology

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