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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Abe, Masumi Fukuma, Aiko Yoshikawa, Rokusuke Miyazawa, Takayuki Yasuda, Jiro |
| Description | Author Affiliation: Abe M ( Fifth Biology Section for Microbiology, First Department of Forensic Science, National Research Institute of Police Science, Kashiwa, 277-0882.) |
| Abstract | PERV is integrated into the genome of all pigs. PERV-A and PERV-B are polytropic and can productively infect human cell lines, whereas PERV-C is ecotropic. Recombinant PERV-A/C can infect human cells and exhibits high titer replication. Therefore, use of pigs for human xenotransplantation raises concerns about the risks of transfer of this infectious agent from donors to xenotransplantation recipients. To establish strategies to inhibit PERV production from cells, in the present study, we investigated the mechanism of PERV budding and anti-PERV activity of Tetherin/BST-2. The results showed that DN mutants of WWP-2, Tsg101, and Vps4A/B markedly reduced PERV production in human and porcine cell lines, suggesting that PERV budding uses these cellular factors and the cellular MVB sorting pathway as well as many other retroviruses. Moreover, PERV production was also reduced by human and porcine Tetherin/BST-2. These data are useful for developing strategies to inhibit PERV production and may reduce the risk of PERV infection in xenotransplantation. |
| File Format | HTM / HTML |
| ISSN | 03855600 |
| Issue Number | 8 |
| Volume Number | 58 |
| e-ISSN | 13480421 |
| Journal | Microbiology and Immunology |
| Language | English |
| Publisher | Wiley-Blackwell |
| Publisher Date | 2014-08-01 |
| Publisher Place | Australia |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Microbiology Discipline Immunology Endogenous Retroviruses Physiology Retroviridae Infections Veterinary Virology Swine Diseases Virus Release Animals Cell Line Down-regulation Genetics Isolation & Purification Humans Receptors, Virus Metabolism Etiology Swine Transplantation, Heterologous Adverse Effects Virus Replication Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Virology Immunology Microbiology |
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