NDLI: Prevalence of coagulation factor XIII and plasminogen activator inhibitor-1 gene polymorphisms among Egyptian women suffering from unexplained primary recurrent miscarriage.

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Prevalence of coagulation factor XIII and plasminogen activator inhibitor-1 gene polymorphisms among Egyptian women suffering from unexplained primary recurrent miscarriage.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Elmahgoub, Iman Rifaat Afify, Reham Abdelaleem Abdel Aal, Asmaa Ahmed El-Sherbiny, Walid Sayed
Spatial Coverage	Egypt
Description	Country affiliation: Egypt Author Affiliation: Elmahgoub IR ( Clinical Pathology Department, Faculty of Medicine, Cairo University, Egypt.); Afify RA ( Clinical Pathology Department, Faculty of Medicine, Cairo University, Egypt.); Abdel Aal AA ( Clinical Pathology Department, Faculty of Medicine, Cairo University, Egypt.); El-Sherbiny WS ( Obstetrics and Gynaecology Department, Faculty of Medicine, Cairo University, Egypt. Electronic address: wssherbiny@kasralainy.edu.eg.)
Abstract	Recurrent miscarriage (RM) is an obstetric challenge. Polymorphisms of factor XIII (FXIII) and plasminogen activator inhibitor-1 (PAI-1) may cause an imbalance between coagulation and fibrinolysis that can end in RM. The aim of the work was to determine the prevalence of FXIII Val34Leu and PAI-1 4G/5G gene polymorphisms in Egyptian women presenting with unexplained primary first trimester RM. Genotyping of 120 unexplained primary first trimester RM patients and 130 healthy controls by polymerase chain reaction (PCR) amplification of target genes followed by the allele-specific restriction enzyme digestion (RFLP technique). Among the cases, 67.5% of individuals had wild-type FXIII; 21.7% were heterozygous and 10.8% were homozygous for the FXIII Val34Leu polymorphism. Among controls, the proportions were 89.2%, 8.5% and 2.3% respectively. In addition, comparison between the two groups regarding Leu and 4G allele frequencies showed statistically significant differences (P values=0.0001 and 0.027 respectively). RM is more frequent in women with combined polymorphisms than in women with a single gene polymorphism (RR=3.91; OR=4.51; 95% CI=1.79-11.38; P=0.002). FXIII Val34Leu and PAI-1 4G/5G polymorphisms are prevalent in Egyptian women, with unexplained primary first trimester RM and combined polymorphisms statistically increasing the risk.
File Format	HTM / HTML
ISSN	01650378
Volume Number	103
e-ISSN	18727603
Journal	Journal of Reproductive Immunology
Language	English
Publisher	Elsevier
Publisher Date	2014-06-01
Publisher Place	Ireland
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Immunology Discipline Reproductive Medicine Abortion, Habitual Genetics Factor Xiii Plasminogen Activator Inhibitor 1 Adult Amino Acid Substitution Case-control Studies Egypt Female Gene Frequency Genetic Predisposition To Disease Genotype Humans Polymorphism, Single Nucleotide Pregnancy Journal Article Observational Study
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology Reproductive Medicine Obstetrics and Gynecology

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