NDLI: Gefitinib in the treatment of nonsmall cell lung cancer with activating epidermal growth factor receptor mutation.

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Year: 2016 Volume: 7 Issue: 1

Gefitinib in the treatment of nonsmall cell lung cancer with activating epidermal growth factor receptor mutation.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Nurwidya, Fariz Takahashi, Fumiyuki Takahashi, Kazuhisa
Description	Country affiliation: Japan Author Affiliation: Nurwidya F ( Department of Respiratory Medicine, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan); Takahashi F ( Department of Respiratory Medicine, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan); Takahashi K ( Department of Respiratory Medicine, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan)
Abstract	Lung cancer is still the main cause of cancer-related deaths worldwide, with most patients present with advanced disease and poor long-term prognosis. The aim of lung cancer treatment is to slow down the progression of the disease, to relieve the patients from the lung cancer symptoms and whenever possible, to increase the overall survival. The discovery of small molecule targeting tyrosine kinase of epidermal growth factor receptor opens a new way in the management of advanced nonsmall cell lung cancer (NSCLC). This review will discuss several Phase II and III trials evaluated the clinical efficacy of gefitinib as monotherapy in pretreated patients with advanced NSCLC, as well as both monotherapy and combined with chemotherapy in chemotherapy-naive patients.
File Format	HTM / HTML
ISSN	09769668
e-ISSN	22297707
DOI	10.4103/0976-9668.184695
Journal	Journal of Natural Science, Biology and Medicine
Issue Number	2
Volume Number	7
Language	English
Publisher	Medknow Publications
Publisher Date	2016-07-01
Publisher Place	India
Access Restriction	Open
Subject Keyword	Discipline Medicine,Biology
Content Type	Text
Resource Type	Article
Subject	Medicine Biochemistry, Genetics and Molecular Biology

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