NDLI: Rhodopsin is spatially heterogeneously distributed in rod outer segment disk membranes.

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Rhodopsin is spatially heterogeneously distributed in rod outer segment disk membranes.

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Rhodopsin is spatially heterogeneously distributed in rod outer segment disk membranes.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Buzhynskyy, Nikolay Salesse, Christian Scheuring, Simon
Description	Country affiliation: France Author Affiliation: Buzhynskyy N ( Institut Curie, U1006INSERM, 26rued'Ulm, 75005 Paris, France.)
Abstract	The visual photoreception takes place in the retina, where specialized rod and cone photoreceptor cells are located. The rod outer segments contain a stack of 500-2,000 sealed membrane disks. Rhodopsin is the visual pigment located in rod outer segment disks, it is a member of the G-protein-coupled receptor (GPCR) superfamily, an important group of membrane proteins responsible for the majority of physiological responses to stimuli such as light, hormones, peptides, etc. Alongside rhodopsin, peripherin/Rom proteins located in the disk rims are thought to be responsible for disk morphology. Here we describe the supramolecular structure of rod outer segment disk membranes and the spatial organization of rhodopsin and peripherin/Rom molecules. Using atomic force microscopy operated in physiological buffer solution, we found that rhodopsin is loosely packed in the central region of the disks, in average about 26 000 molecules covering approximately one third of the disk surface. Peripherin/Rom proteins form dense assemblies in the rim region. A protein-free lipid bilayer girdle separates the rhodopsin and peripherin/Rom domains. The described supramolecular assembly of rhodospin, peripherin/Rom and lipids in native rod outer segment disks is consistent with the functional requirements of photoreception.
File Format	HTM / HTML
ISSN	09523499
Issue Number	3
Volume Number	24
e-ISSN	10991352
Journal	Journal of Molecular Recognition
Language	English
Publisher	Wiley
Publisher Date	2011-05-01
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Molecular Biology Rhodopsin Metabolism Rod Cell Outer Segment Animals Antibodies, Monoclonal Cattle Intermediate Filament Proteins Membrane Glycoproteins Membrane Proteins Nerve Tissue Proteins Peripherins Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Structural Biology Molecular Biology

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