NDLI: Severe axillary lymphadenitis after BCG vaccination: alert for primary immunodeficiencies.

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Severe axillary lymphadenitis after BCG vaccination: alert for primary immunodeficiencies.

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Severe axillary lymphadenitis after BCG vaccination: alert for primary immunodeficiencies.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Santos, Alexandra Dias, Andrea Cordeiro, Ana Cordinhã, Carolina Lemos, Sónia Rocha, Graça Faria, Emília
Description	Country affiliation: Portugal Author Affiliation: Santos A ( Medical Inpatient Department, Coimbra Pediatric Hospital, Coimbra, Portugal. alexandrafigueirasantos@gmail.com)
Abstract	The bacilli Calmette-Guérin (BCG) vaccine is administered to all newborns in countries where tuberculosis is endemic. Immunocompromised hosts, namely patients with human immunodeficiency virus infection or primary immunodeficiencies, are especially prone to serious complications from this vaccine. We report three cases of BCG disease in children with primary immunodeficiencies: one with a partial recessive interferon-Î³ receptor 1 deficiency, who developed BCG dissemination; and two relatives with ZAP70 deficiency, a severe combined immunodeficiency, both of whom presented with regional and distant BCG disease. All had severe axillary lymphadenitis. These clinical cases underline the importance of considering the diagnosis of immunodeficiency in a child with severe axillary lymphadenitis after BCG vaccination and of disseminated BCG disease in an immunodeficient child in the appropriate clinical setting. Moreover, BCG vaccination should be delayed in every newborn with a family history of primary immunodeficiency until the condition has been ruled out.
File Format	HTM / HTML
ISSN	16841182
e-ISSN	19959133
Journal	Journal of Microbiology, Immunology and Infection
Issue Number	6
Volume Number	43
Language	English
Publisher	Elsevier
Publisher Date	2010-12-01
Publisher Place	Great Britain (UK)
Access Restriction	Open
Subject Keyword	Discipline Microbiology Discipline Immunology Bcg Vaccine Adverse Effects Immunologic Deficiency Syndromes Complications Lymphadenitis Microbiology Receptors, Interferon Deficiency Tuberculosis Administration & Dosage Infant Mycobacterium Bovis Immunology Severe Combined Immunodeficiency Diagnosis Prevention & Control Vaccination Zap-70 Protein-tyrosine Kinase
Content Type	Text
Resource Type	Case study Article
Subject	Infectious Diseases Immunology and Microbiology Immunology and Allergy Microbiology (medical)

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