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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Rosenberg, Steven A. Spiess, Paul J. Kleiner, David E. |
| Description | Country affiliation: United States Author Affiliation: Rosenberg SA ( Surgery Branch and Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, Building 10, Room 2B42, 9000 Rockville Pike, Bethesda, MD 20892, USA.) |
| Abstract | Salmonella typhimurium genetically modified at the purI and msbB genes to increase dependence on adenine and decrease stimulation of tumor necrosis factor-alpha production were injected intravenously into C57BL/6 mice bearing subcutaneous tumor or lung metastases. Decreased tumor growth and prolonged survival were seen in some, but not all of nine transplantable tumors. Salmonella increased in number in the tumor and reached levels 10,000 times higher than in the normal liver reservoir of these bacteria. Histologic studies revealed Salmonella growth in areas of the tumor although, in all cases, a viable rim of tumor survived and ultimately resulted in progressive tumor growth in all mice. These studies demonstrate that Salmonella can localize to transplantable murine tumors and partially inhibit tumor growth; however, additional modifications of the bacteria may be necessary if this approach is to develop into an effective treatment for patients with cancer. |
| File Format | HTM / HTML |
| ISSN | 15249557 |
| e-ISSN | 15374513 |
| Journal | Journal of Immunotherapy |
| Issue Number | 3 |
| Volume Number | 25 |
| Language | English |
| Publisher | Lippincott Williams & Wilkins |
| Publisher Date | 2002-05-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Discipline Immunology Discipline Therapeutics Neoplasms, Experimental Therapy Salmonella Typhimurium Immunology Animals Injections, Intravenous Liver Microbiology Pathology Mice Mice, Inbred C57bl Research Support, U.s. Gov't, P.h.s. |
| Content Type | Text |
| Resource Type | Article |
| Subject | Immunology and Allergy Cancer Research Immunology Pharmacology |
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