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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Gigante, Margherita Mandic, Maja Wesa, Amy K. Cavalcanti, Elisabetta Dambrosio, Michele Mancini, Vito Battaglia, Michele Gesualdo, Loreto Storkus, Walter J. Ranieri, Elena |
| Description | Country affiliation: Italy Author Affiliation: Gigante M ( Department of Biomedical Sciences, University of Foggia, Foggia, Italy.) |
| Abstract | Dendritic cells (DCs) are potent antigen presenting cells and represent attractive candidates for use in novel immunotherapies for patients with renal cell carcinoma (RCC), a disease that has proven refractory to conventional treatment modalities, such as chemotherapy and radiotherapy. Given the perceived need to augment antitumor type-1 immunity (TC1 and Th1) as a therapeutic end point, and the known functional plasticity of DC populations that may display heterogeneous capacity to promote T-cell responses, we sought to identify a preferred DC preparation with this capacity. We compared 2 different preparations of monocyte-derived DC using interferon-alpha (IFN-alpha) (IFN-DC and alphaDC1) with classic DCs 'matured' (mDCs) using interleukin-1beta/interleukin-6/tumor necrosis factor-alpha/prostaglandin E2, for their ability to promote autologous TC1 antitumor responses from RCC patients in vitro. IFN-alpha-conditioned DC promoted significantly higher numbers of RCC-specific CD8+ T cells exhibiting a cytotoxic phenotype after in vitro stimulation (IVS) than cytokine cocktail-mDCs. Furthermore, IVS using IFN-DCs was able to diminish regulatory-type T cells among CD4+ T-cell responder populations versus IVS using conventional mDC-based vaccines. These data emphasize an important role for IFN-alpha in modulating the immunologic functions of DCs toward a polarized DC1-type capable of coordinately promoting TH1-type and TC1-type T-cell mediated immunity and supports the translational development of patient-derived IFN-alpha-conditioned DC for use in novel immunotherapies for patients with RCC, and in whom, endogenous tumor-specific TC1 effector cells may be dysfunctional, anergic, or prone to undergo apoptosis. |
| File Format | HTM / HTML |
| ISSN | 15249557 |
| Issue Number | 3 |
| Volume Number | 31 |
| e-ISSN | 15374513 |
| Journal | Journal of Immunotherapy |
| Language | English |
| Publisher | Lippincott Williams & Wilkins |
| Publisher Date | 2008-04-01 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Immunology Discipline Therapeutics Carcinoma, Renal Cell Immunology Dendritic Cells Interferon-alpha Kidney Neoplasms Lymphocyte Activation T-lymphocytes, Regulatory Th1 Cells Blood Pathology Cell Communication Cell Differentiation Drug Effects Cells, Cultured Cytokines Cytotoxicity, Immunologic Humans Immunologic Memory Immunotherapy, Active Interferon Type I Pharmacology Metabolism Interferon-gamma Recombinant Proteins Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Immunology and Allergy Cancer Research Immunology Pharmacology |
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