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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Reddy, Cara Camiolo Collins, Michael Lovell, Mark Kontos, Anthony P. |
| Description | Country affiliation: United States Author Affiliation: Reddy CC ( Department of Physical Medicine and Rehabilitation, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15219, USA. camice@upmc.edu) |
| Abstract | OBJECTIVE: To evaluate the efficacy of amantadine in the treatment of symptoms and neurocognitive performance in adolescents following sports-related concussion. PARTICIPANTS: A clinical sample of 25 male (n = 11) and female (n = 14) adolescent subjects with an age-, sex-, and concussion history-matched group of 25 male (n = 11) and female (n = 14) control subjects. SETTING: Outpatient concussion clinic. INTERVENTION: Retrospective, case-control design. Treatment group consisted of patients treated with 100 mg of amantadine twice daily (200 mg total per day) following a period of rest. Matched controls were evaluated and treated conservatively without medication at the same concussion program prior to the start of the current amantadine protocol. MAIN OUTCOME MEASURES: Immediate Postconcussion Assessment and Cognitive Test computerized neurocognitive test battery and symptom report. RESULTS: Results support significantly greater improvements from pre- to posttest in reported symptoms, verbal memory, and reaction time performance for the amantadine group than the matched controls. There were no significant differences for visual memory or visual motor processing speed. CONCLUSION: This study provides empirical support for amantadine as an effective pharmacologic treatment of certain concussion-related cognitive deficits and symptoms in athletes with protracted recovery of more than 3 weeks. |
| File Format | HTM / HTML |
| ISSN | 08859701 |
| Issue Number | 4 |
| Volume Number | 28 |
| e-ISSN | 1550509X |
| Journal | Journal of Head Trauma Rehabilitation |
| Language | English |
| Publisher | Lippincott Williams & Wilkins |
| Publisher Date | 2013-07-01 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Physical and Rehabilitation Medicine Discipline Traumatology Amantadine Therapeutic Use Athletic Injuries Drug Therapy Brain Concussion Diagnosis Dopamine Agents Adolescent Analysis Of Variance Case-control Studies Cognition Drug Effects Cognition Disorders Etiology Dose-response Relationship, Drug Drug Administration Schedule Female Follow-up Studies Humans Injury Severity Score Male Memory Neuropsychological Tests Reaction Time Reference Values Retrospective Studies Sports Treatment Outcome Journal Article |
| Content Type | Text |
| Resource Type | Article |
| Subject | Rehabilitation Physical Therapy, Sports Therapy and Rehabilitation Neurology (clinical) |
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