NDLI: An evaluation of metrics for assessing maternal exposure to agricultural pesticides.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Warren, Joshua L. Luben, Thomas J. Sanders, Alison P. Brownstein, Naomi C. Herring, Amy H. Meyer, Robert E.
Spatial Coverage	North Carolina
Description	Country affiliation: United States Author Affiliation: Warren JL ( Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.); Luben TJ ( National Center for Environmental Assessment, United States Environmental Protection Agency, Research Triangle Park, North Carolina, USA.); Sanders AP ( Department of Environmental Sciences and Engineering, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.); Brownstein NC ( Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.); Herring AH ( Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.); Meyer RE ( Birth Defects Monitoring Program, State Center for Health Statistics, North Carolina Division of Public Health, Raleigh, North Carolina, USA.)
Abstract	We evaluate the use of three different exposure metrics to estimate maternal agricultural pesticide exposure during pregnancy. Using a geographic information system-based method of pesticide exposure estimation, we combine data on crop density and specific pesticide application amounts/dates to create the three exposure metrics. For illustration purposes, we create each metric for a North Carolina cohort of pregnant women, 2003-2005, and analyze the risk of congenital anomaly development with a focus on metric comparisons. Based on the results, and the need to balance data collection efforts/computational efficiency with accuracy, the metric which estimates total chemical exposure using application dates based on crop-specific earliest planting and latest harvesting information is preferred. Benefits and drawbacks of each metric are discussed and recommendations for extending the analysis to other states are provided.
File Format	HTM / HTML
ISSN	15590631
e-ISSN	1559064X
DOI	10.1038/jes.2013.75
Journal	Journal of Exposure Science and Environmental Epidemiology
Issue Number	5
Volume Number	24
Language	English
Publisher	Macmillan Publishers Limited
Publisher Date	2014-09-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline Environmental Health Discipline Epidemiology Environmental Exposure Maternal Exposure Pesticides Toxicity Cohort Studies Evaluation Studies As Topic North Carolina Pregnancy Risk Factors Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Pollution Public Health, Environmental and Occupational Health Toxicology Epidemiology

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