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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Huang, Yao-Kang Wu, Meng-Chieh Wang, Sophie Sw Kuo, Chao-Hung Lee, Yi-Chern Chang, Ling-Li Wang, Tsung-Hsi Chen, Yen-Hsu Wang, Wen-Ming Wu, Deng-Chyang Kuo, Fu-Chen |
| Description | Country affiliation: China Author Affiliation: Huang YK ( Division of Gastroenterology, Department of Internal Medicine, Ten Chan Hospital, Chung-Li, Taoyuan, China.) |
| Abstract | OBJECTIVE: The aim of this prospective study was to compare the efficacy of the first-line lansoprazole-based sequential therapy and concomitant therapy (lansoprazole, amoxicillin, clarithromycin and metronidazole) for Helicobacter pylori (H. pylori) eradication. METHODS: A total of 169 patients with H. pylori infection were randomly assigned to either the sequential therapy group (n = 85) or the concomitant therapy group (n = 84). A follow-up endoscopy or urea breath test was examined at least 12 weeks after eradication. RESULTS: Comparable H. pylori eradication rate was observed in both the sequential therapy and concomitant therapy groups by either intention-to-treat analysis [sequential 80.0% (68/85) vs concomitant 88.1% (74/84); P = 0.27] or per protocol analysis [sequential, 85.3% (64/75) vs concomitant, 94.6% (70/74); P = 0.60]. Adverse effects were reported and good compliance was observed in both groups (P = 0.72). Although dual antibiotics resistance affected the therapeutic efficacy of sequential therapy (P = 0.03), not concomitant therapy (P = 0.74), it was not an independent factor for predicting the treatment outcome. CONCLUSION: First-line lansoprazole-based sequential and concomitant therapy were well-tolerated and comparable in terms of their H. pylori eradication rate. |
| File Format | HTM / HTML |
| ISSN | 17512972 |
| Issue Number | 4 |
| Volume Number | 13 |
| e-ISSN | 17512980 |
| Journal | Journal of Digestive Diseases |
| Language | English |
| Publisher | Wiley-Blackwell |
| Publisher Date | 2012-04-01 |
| Publisher Place | Australia |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Gastroenterology 2-pyridinylmethylsulfinylbenzimidazoles Administration & Dosage Amoxicillin Clarithromycin Helicobacter Infections Drug Therapy Helicobacter Pylori Drug Effects Metronidazole Adult Aged Anti-bacterial Agents Anti-infective Agents Anti-ulcer Agents Drug Therapy, Combination Female Gastritis Microbiology Pathology Complications Humans Lansoprazole Male Middle Aged Prospective Studies Treatment Outcome Comparative Study Journal Article Randomized Controlled Trial Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Gastroenterology |
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