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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Gao, Yu Jing, Ming Ge, Rongrong Zhou, Zhe Sun, Yan |
| Description | Author Affiliation: Gao Y ( Department of Ophthalmology, No. 411 Hospital of CPLA, Shanghai, 200081, People's Republic of China. gaoyu7607@gmail.com.) |
| Abstract | Hypoxia, which activates the hypoxia inducible factor 1 (HIF-1 ), is an essential feature of retinoblastoma (RB) and contributes to poor prognosis and resistance to conventional therapy. In this study, the effect of HIF-1 knockdown by small interfering RNA (siRNA) on cell proliferation, apoptosis, and apoptotic pathways of human Y-79 RB cells was first investigated. Exposure to hypoxia induced the increased expression of HIF-1 both in mRNA and protein levels. Then, knockdown of HIF-1 by siRNAHIF-1 resulted in inhibition of cell proliferation and induced cell apoptosis in human Y-79 RB cells under both normoxic and hypoxic conditions, with hypoxic conditions being more sensitive. Furthermore, knockdown of HIF-1 could enhance hypoxia-induced slight increase of Bax/Bcl-2 ratio and activate caspase-9 and caspase-3. These results together indicated that suppression of HIF-1 expression may be a promising strategy for the treatment of human RB in the future. |
| File Format | HTM / HTML |
| ISSN | 10956670 |
| Issue Number | 9 |
| Volume Number | 28 |
| e-ISSN | 10990461 |
| Journal | Journal of Biochemical and Molecular Toxicology |
| Language | English |
| Publisher | Wiley |
| Publisher Date | 2014-09-01 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Molecular Biology Discipline Biochemistry Discipline Toxicology Apoptosis Drug Effects Hypoxia-inducible Factor 1, Alpha Subunit Metabolism Neoplasm Proteins Rna, Small Interfering Pharmacology Genetics Caspase 3 Caspase 9 Cell Hypoxia Cell Line, Tumor Humans Proto-oncogene Proteins C-bcl-2 Rna, Messenger Rna, Neoplasm Retinoblastoma Bcl-2-associated X Protein Journal Article |
| Content Type | Text |
| Resource Type | Article |
| Subject | Health, Toxicology and Mutagenesis Medicine Molecular Biology Biochemistry Toxicology Molecular Medicine |
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