NDLI: Delirium in the intensive care unit.

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Delirium in the intensive care unit.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Morandi, Alessandro Jackson, James C. Ely, E. Wesley
Description	Country affiliation: United States Author Affiliation: Morandi A ( Center for Health Services Research, Vanderbilt Medical Center, Nashville, Tennessee 37232-8300, USA.)
Abstract	Delirium is a common manifestation of acute brain dysfunction in critically ill patients with prevalence as high as 75%. In the last years there has been a progressive increase of publications regarding intensive care (ICU) delirium, acknowledging its importance. The occurrence of delirium in ICU is related to more adverse outcomes including self-extubation and removal of catheters, prolonged hospitalization, increased costs, higher mortality, and potentially, long-term cognitive impairment. The pathophysiology explaining the processes subtending the development of delirium is still elusive, though several theories have been discussed. It is known that different risk factors are associated with delirium in the ICU. Patients in ICU frequently receive medications to treat pain and to ensure sedation, but an association between these drugs and delirium has been shown. Therefore, this pharmacological exposure should be modified to reduce the risk factors. Giving the multifactorial genesis of delirium, multicomponent interventions to prevent delirium developed in non-ICU settings can be adapted to critically ill patients with the purpose of reducing the incidence. When delirium is diagnosed the use of typical and atypical antipsychotics may be effective for its treatment. Future studies should evaluate target interventions to prevent delirium in the ICU.
File Format	HTM / HTML
ISSN	09540261
Issue Number	1
Volume Number	21
e-ISSN	13691627
Journal	International Review of Psychiatry
Language	English
Publisher	Taylor & Francis
Publisher Date	2009-02-01
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Psychiatry Delirium Epidemiology Rehabilitation Intensive Care Units Statistics & Numerical Data Classification Humans Psychomotor Disorders Physiopathology Journal Article Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't Research Support, U.s. Gov't, Non-p.h.s. Review
Content Type	Text
Resource Type	Article
Subject	Psychiatry and Mental Health

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