NDLI: Hen egg chorioallantoic membrane bioassay: an in vitro alternative to draize eye irritation test for pesticide screening.

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Hen egg chorioallantoic membrane bioassay: an in vitro alternative to draize eye irritation test for pesticide screening.

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Hen egg chorioallantoic membrane bioassay: an in vitro alternative to draize eye irritation test for pesticide screening.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Kishore, A. S. Surekha, P. A. Sekhar, P. V. R. Srinivas, A. Murthy, P. Balakrishna
Description	Country affiliation: India Author Affiliation: Kishore AS ( Director, International Institute of Biotechnology and Toxicology (IIBAT), Padappai-601 301, Tamil Nadu, India.)
Abstract	As an alternative to the standard Draize eye irritation test, the potential irritancy of compounds was evaluated by observing adverse changes that occur in chorioallantoic membrane CAM) of the hen egg (HECAM) after exposure to a test chemical placed directly on the CAM. The occurrence of hemorrhage, coagulation, and lysis in response to a test compound is the basis for employing this technique to evaluate its potential for in vivo damage to mucous membrane, in particular the eye. Irritancy is scored according to the severity and speed at which damage occurs. In the present study, five different classes of pesticides were screened for irritation potential. There was good correlation between the HECAM assay and the in vivo Draize eye irritation test. The proposed HECAM assay, which reduces the requirement for laboratory animals, could be a painless alternative to the Draize test.
File Format	HTM / HTML
ISSN	10915818
Issue Number	6
Volume Number	27
e-ISSN	1092874X
Journal	International Journal of Toxicology
Language	English
Publisher	Sage Publication
Publisher Date	2008-11-01
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Toxicology Allantois Drug Effects Animal Testing Alternatives Chorion Eye Irritants Toxicity Pesticides Animals Biological Assay Chick Embryo Journal Article
Content Type	Text
Resource Type	Article
Subject	Toxicology

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Hen egg chorioallantoic membrane bioassay: an in vitro alternative to draize eye irritation test for pesticide screening.