NDLI: A novel HLA-B*40 sequence--B*40:92.

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A novel HLA-B40 sequence--B40:92.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Street, J. Johnson, J. Hammond, L. Pepperall, J. Darke, C.
Description	Country affiliation: United kingdom Author Affiliation: Street J ( Welsh Transplantation and Immunogenetics Laboratory, Welsh Blood Service, Pontyclun, Wales, UK.)
Abstract	A new allele, HLA-B40:92, was identified in a north-western European subject during polymerase chain reaction using sequence-specific priming (PCR-SSP)-based typing of haematopoietic stem cell (HSC) donors. B40:92 differs from B40:01:01 by six nucleotides at positions 559, 560, 603, 605, 610 and 618 in exon 3 which represents a substitution motif of at least 60 nucleotides. This motif, which occurs in numerous HLA alleles including the relatively high frequency B15 and B35 allele families, encode four amino acid changes at positions 163 (glutamic acid > leucine), 177 (aspartic acid > glutamic acid), 178 (lysine > threonine), 180 (glutamic acid > glutamine) and a silent substitution, conserved alanine, at codon 182. Thus, it is likely that HLA-B40:92 occurred following a gene conversion-like or interallelic recombination event involving B40:01:01 and probably a B15 or more likely a B35 family allele. HLA-B40:92 was found on a haplotype with HLA-A02:01, B40:92, C03:04, DRB113:02, DRB303:01, DQA101:02, DQB106:04, DPA102:02, DPB105:01. Tests on 69 selected B40 and B35 antisera and Lambda Monoclonal Trays™ show that B40:92 encodes a 'short' B40/B60 serological specificity which displays some HLA-B35 reactivity. The HLA-B40 and HLA-B35 motifs (possible epitopes) responsible for this serological reactivity were identified. This single example of HLA- B40:92 was found in 56,823 consecutive HLA PCR-SSP typed HSC donors indicating a carriage frequency of 0.00176% (allele frequency 0.00001) in blood donors resident in Wales. An Epstein-Barr virus transformed B-cell line from the HLA-B40:92 donor is available.
File Format	HTM / HTML
ISSN	17443121
Issue Number	2
Volume Number	38
e-ISSN	1744313X
Journal	International Journal of Immunogenetics
Language	English
Publisher	Wiley-Blackwell
Publisher Date	2011-04-01
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Genetics Discipline Immunology Alleles Hla-b Antigens Genetics Antibody Specificity Immunology Base Sequence Exons Hla-b40 Antigen Humans Molecular Sequence Data Regulatory Sequences, Nucleic Acid Sequence Alignment Journal Article
Content Type	Text
Resource Type	Article
Subject	Genetics Molecular Biology Immunology Genetics (clinical)

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