NDLI: A review of the tissue residue approach for organic and organometallic compounds in aquatic organisms.

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A review of the tissue residue approach for organic and organometallic compounds in aquatic organisms.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	McElroy, Anne E. Barron, Mace G. Beckvar, Nancy Driscoll, Susan B. Kane Meador, James P. Parkerton, Tom F. Preuss, Thomas G. Steevens, Jeffery A.
Description	Country affiliation: United States Author Affiliation: McElroy AE ( School of Marine and Atmospheric Sciences, Stony Brook University, Stony Brook, New York 11794-5000, USA. anne.mcelroy@stonybrook.edu)
Abstract	This paper reviews the tissue residue approach (TRA) for toxicity assessment as it applies to organic chemicals and some organometallic compounds (Sn, Hg, and Pb) in aquatic organisms. Specific emphasis was placed on evaluating key factors that influence interpretation of critical body residue (CBR) toxicity metrics including data quality issues, lipid dynamics, choice of endpoints, processes that alter toxicokinetics and toxicodynamics, phototoxicity, species- and life stage-specific sensitivities, and biotransformation. The vast majority of data available on TRA is derived from laboratory studies of acute lethal responses to organic toxicants exhibiting baseline toxicity. Application of the TRA to various baseline toxicants as well as substances with specific modes of action via receptor-mediated processes, such as chlorinated aromatic hydrocarbons, pesticides, and organometallics is discussed, as is application of TRA concepts in field assessments of tissue residues. In contrast to media-based toxicity relationships, CBR values tend to be less variable and less influenced by factors that control bioavailability and bioaccumulation, and TRA can be used to infer mechanisms of toxic action, evaluate the toxicity of mixtures, and interpret field data on bioaccumulated toxicants. If residue-effects data are not available, body residues can be estimated, as has been done using the target lipid model for baseline toxicants, to derive critical values for risk assessment. One of the primary unresolved issues complicating TRA for organic chemicals is biotransformation. Further work on the influence of biotransformation, a better understanding of contaminant lipid interactions, and an explicit understanding of the time dependency of CBRs and receptor-mediated toxicity are all required to advance this field. Additional residue-effects data on sublethal endpoints, early life stages, and a wider range of legacy and emergent contaminants will be needed to improve the ability to use TRA for organic and organometallic compounds.
File Format	HTM / HTML
ISSN	15513777
Issue Number	1
Volume Number	7
e-ISSN	15513793
Journal	Integrated Environmental Assessment and Management
Language	English
Publisher	Wiley Society of Environmental Toxicology and Chemistry (SETAC)
Publisher Date	2011-01-01
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Environmental Health Organometallic Compounds Pharmacokinetics Toxicity Water Pollutants, Chemical Animals Aquatic Organisms Biotransformation Kinetics Lipids Metabolism Tissue Distribution Journal Article Research Support, Non-u.s. Gov't Review
Content Type	Text
Resource Type	Article
Subject	Geography, Planning and Development Medicine Environmental Science

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