NDLI: Polymorphisms of STAT6 and specific serum IgE levels in patients with penicillin allergy.

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Polymorphisms of STAT6 and specific serum IgE levels in patients with penicillin allergy.

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Polymorphisms of STAT6 and specific serum IgE levels in patients with penicillin allergy.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Huang, Chen-Zheng Zou, Dan Yang, Jing Qiao, Hai-Ling
Description	Country affiliation: China Author Affiliation: Huang CZ ( Department of Clinical Pharmacology, Zhengzhou University, Zhengzhou, China.)
Abstract	OBJECTIVE: Signal transducer and activator of transcription (STAT) 6 signaling pathway is required for mediating the biologic functions of interleukin (IL)-4 which is proved to play an important role in the pathogenesis of allergic diseases and the induction of specific immunoglobulin (Ig) E synthesis. The current studies are conducted to evaluate the relationship between polymorphisms of STAT6, specific IgE and penicillin allergy. MATERIALS AND METHODS: In 242 patients with penicillin allergy and 220 controls, polymorphisms of STAT6 in2SNP3 and 3'UTRSNP3 were genotyped by polymerase chain reaction- restriction fragment length polymorphism (PCR-RFLP). Eight kinds of specific IgE to penicillins were detected with radioallergosorbent test (RAST). RESULTS: For STAT6 in2SNP3, the frequency of the CC genotype was significantly higher in all patients than in controls (60 vs. 47%, p = 0.005). A similar result was observed between patients of the urticaria group and controls (70 vs. 47%, p = 0.005). With respect to allele frequency, the C-allele occurred more frequently in all patients and in the urticaria group than in controls (78 vs. 69%, p = 0.002; 83 vs. 69%, p = 0.007). CONCLUSIONS: Our finding suggests that STAT6 in2SNP3 is associated with penicillin allergy, but has no effect on the specific IgE levels of patients with penicillin allergy.
File Format	HTM / HTML
ISSN	09461965
Issue Number	7
Volume Number	50
Journal	Int. Journal of Clinical Pharmacology and Therapeutics
Language	English
Publisher	Dustri-Verlag
Publisher Date	2012-07-01
Publisher Place	Germany
Access Restriction	Subscribed
Subject Keyword	Discipline Pharmacology Drug Hypersensitivity Genetics Immunoglobulin E Blood Penicillins Adverse Effects Polymorphism, Single Nucleotide Stat6 Transcription Factor Adolescent Adult Immunology Female Gene Frequency Genotype Humans Male Prospective Studies Young Adult Journal Article
Content Type	Text
Resource Type	Article
Subject	Pharmacology Pharmacology (medical)

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