NDLI: Drug interactions between micafungin at high doses and cyclosporine A in febrile neutropenia patients after allogeneic hematopoietic stem cell transplantation.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Inoue, Yasuyuki Saito, Tasuku Ogawa, Kohei Nishio, Yuji Kosugi, Shigeki Suzuki, Yoshinori Kato, Masayuki Sakai, Takahiro Takahashi, Masatomo Miura, Ikuo
Spatial Coverage	Japan
Description	Country affiliation: Japan Author Affiliation: Inoue Y ( Division of Hematology and Oncology, Department of Internal Medicine, St. Marianna University, School of Medicine, 2-16-1 Sugao, Miyamae-ku, Kawasaki 216-8511, Japan. ino-yasu@marianna-u.ac.jp)
Abstract	OBJECTIVES: The aim of this study was to assess the drug interaction between high doses of micafungin and cyclosporine A (CyA) in allo-HSCT patients. METHODS: We assigned 15 patients to Groups 1, 2, or 3. We investigated the serial changes in the blood concentration/dose (C/dose) of intravenous CyA during micafungin coadministration in 5 patients during the switch from the prophylactic dose (150 mg/body) to the therapeutic dose (300 mg/body) of micafungin (Group 1), and compared each of the 5 patients in Group 1 with those who continued to receive the prophylactic doses of 150 mg or 50 mg/body of micafungin (Groups 2 and 3). We collected blood samples from patients in Group 1 receiving CyA at 0 h (C0) and (C3) 3 h on the 7th day after allo-HSCT, and on the 3rd and 10th days after escalation of the dose of micafungin to 300 mg. RESULTS: In Group 1, no significant difference was observed between C0/dose (2.11 ± 0.14) and C3/dose ratios of CyA (11.1 ± 5.34, p > 0.05) under 150 mg; the C0/dose and C3/dose ratios of CyA were 2.40 ± 0.60 and 10.8 ± 4.72 on the 3rd day and 2.23 ± 0.41 and 11.8 ± 3.06 on the 10th day, respectively, after dose escalation of micafungin to 300 mg. No significant differences were observed in those ratios between Groups 1 and 2 and between Groups 1 and 3. CONCLUSION: Thus, high dose of micafungin seems to be safe and does not significantly interact with CyA in allo-HSCT.
File Format	HTM / HTML
ISSN	09461965
Issue Number	11
Volume Number	50
Journal	Int. Journal of Clinical Pharmacology and Therapeutics
Language	English
Publisher	Dustri-Verlag
Publisher Date	2012-11-01
Publisher Place	Germany
Access Restriction	Subscribed
Subject Keyword	Discipline Pharmacology Antifungal Agents Administration & Dosage Cyclosporine Pharmacokinetics Echinocandins Fever Drug Therapy Hematopoietic Stem Cell Transplantation Adverse Effects Immunosuppressive Agents Lipopeptides Neutropenia Diagnosis Adult Aged Analysis Of Variance Blood Drug Interactions Drug Monitoring Female Etiology Humans Japan Male Middle Aged Models, Biological Pilot Projects Journal Article Randomized Controlled Trial
Content Type	Text
Resource Type	Article
Subject	Pharmacology Pharmacology (medical)

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