NDLI: Chemical modification of high density lipoprotein subfractions - HDL2 and HDL3

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	de Souza Zago, Vanessa Helena Tanus-Santos, José Eduardo Gardin Danelon, Mirian Regina Parra, Eliane Soler Alexandre, Fernanda Vieira, Isabela Calanca Panzoldo, Natália Baratella D'Alexandri, Fábio Luís Rocha Quintão, Eder Carlos de Faria, Eliana Cotta
Abstract	Regardless of its effect on the concentrations of serum cholesterol, statins exert pleiotropic effects, including the regulation of endothelial function, reduced oxidative stress and inflammation, as well as a slight improvement in the concentrations of high density lipoprotein (HDL). However, its role on the composition of HDL is not yet established. The aim of this study was to evaluate the composition of HDL subfractions, HDLsub>2 and HDL3, after 14 days of placebo and atorvastatin (10 mg/day) use in 30 asymptomatic volunteers. The serum parameters and the HDL subfractions compositions were determined using radiometric, nephelometric and biochemical enzymatic methods. We observed significant reductions of total cholesterol, low density lipoprotein (LDL) and apolipoprotein B-100 by 28%, 40% and 38%, respectively. The analyses of chemical composition of the subfractions revealed a lower lipid protein ratio in HDL2, suggesting enrichment in proteins, and also lower in HDL3, probably by an increase in the number of particles. Several mechanisms can be suggested for the effects observed after the use of atorvastatin, such as a possible action on the reverse cholesterol transport (decreased activity of hepatic lipase and increased phospholipid transfer protein, PLTP), which would explain the enrichment of HDL. The results suggest that statin use may be relevant in the primary prevention of atherosclerosis not only by its lowering effect on LDLcholesterol and its anti-inflammatory effect but also by beneficial changes in HDL subfractions.
File Format	HTM / HTML
ISSN	09461965
Issue Number	4
Volume Number	52
Journal	Int. Journal of Clinical Pharmacology and Therapeutics
Language	English
Publisher	Dustri-Verlag
Publisher Date	2014-04-01
Publisher Place	Germany
Access Restriction	Subscribed
Subject Keyword	Discipline Pharmacology Heptanoic Acids Pharmacology Hydroxymethylglutaryl-coa Reductase Inhibitors Lipoproteins, Hdl2 Analysis Lipoproteins, Hdl3 Pyrroles Adult Atorvastatin Calcium Humans Male Journal Article Randomized Controlled Trial Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Pharmacology Pharmacology (medical)

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