NDLI: Efficacy and prognosis of neoadjuvant chemotherapy is correlated with breast cancer molecular classification.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Dai, Xiao-li Han, Zhong-bao Yang, You-tian Qiu, Jing Liu, Yi-fei Feng, Yi-zhong
Abstract	Breast cancer is one of the most common cancers affecting women globally. Recent studies have begun to investigate the possibility of customized treatment options for individuals based on the specific cancer type. Here, we sought to analyze the relationship between the molecular classification of breast cancer and the efficacy and prognosis of neoadjuvant chemotherapy (NCT). The study included 100 breast cancer patients treated with an NCT regimen of epirubicin and docetaxel (ET) who were divided into groups based on cancer subtype (luminal, HER2 over-expression, and basal-like subtype). The nuclear classification, number of NCT cycles, pathological remission rate, and clinical curative effect, as well as the disease-free survival time (DFS) and the overall survival (OS), were compared across groups. The nuclear grade of participants in the basal-like group was significantly higher than those in the other groups but this group had fewer preoperative NCT cycles and lower pathological remission and clinical efficacy (Z=53.245, 50.077, 62.467, χ2=16.082, p<0.05). The OS and DFS of participants in the luminal subtype group were significantly higher than those in other groups while those in the basal-like subtype group were the lowest. The OS and DFS of participants who achieved pathological complete remission (pCR) through NCT treatment were significantly higher than those of the patients who had not achieved pCR through NCT treatment (χ2=9.558, 10.139, p<0.05). Therefore, we conclude that when NCT (ET regimen) is used in the treatment of breast cancer, the curative effects and prognosis appear to be correlated with the molecular classification of the tumor. Based on these results, clinicians should consider the molecular classification of the individual tumor to design the most effective treatment option.
File Format	HTM / HTML
ISSN	09461965
Issue Number	7
Volume Number	53
Journal	Int. Journal of Clinical Pharmacology and Therapeutics
Language	English
Publisher	Dustri-Verlag
Publisher Date	2015-07-01
Publisher Place	Germany
Access Restriction	Subscribed
Subject Keyword	Discipline Pharmacology Antineoplastic Combined Chemotherapy Protocols Therapeutic Use Tumor Markers, Biological Analysis Breast Neoplasms Drug Therapy Neoadjuvant Therapy Chemistry Classification Mortality Pathology Chemotherapy, Adjuvant Chi-square Distribution Disease Progression Disease-free Survival Epirubicin Administration & Dosage Female Humans Kaplan-meier Estimate Neoplasm Grading Individualized Medicine Predictive Value Of Tests Receptor, Erbb-2 Receptors, Estrogen Receptors, Progesterone Remission Induction Risk Factors Taxoids Time Factors Treatment Outcome Journal Article
Content Type	Text
Resource Type	Article
Subject	Pharmacology Pharmacology (medical)

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