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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Jung, Jae Hyun Song, Gwan Gyu Lee, Young Ho |
| Description | Author Affiliation: Jung JH ( Division of Rheumatology, Department of Internal Medicine, Korea University College of Medicine , Seoul , Korea.) |
| Abstract | OBJECTIVE: This study determined whether interleukin-10 (IL-10) polymorphisms are associated with susceptibility to vasculitis. METHODS: A meta-analysis was conducted of the associations between the IL-10 -1082 G/A, -819 C/T, and -592 C/A polymorphisms and the haplotype of the IL-10-1082 G/A, -819 C/T, -592 C/A polymorphisms and vasculitis. RESULTS: A total of 21 comparative studies involving 4121 patients and 5504 controls were considered in the meta-analysis. Meta-analysis revealed no association between the IL-10-1082 G allele and vasculitis in all study subjects (OR = 0.927, 95% CI = 0.780-1.102, p = 0.389). However, disease-specific meta-analysis showed an association between Wegener's granulomatosis (WG) and the IL-10-1082 G allele (OR = 0.729, 95% CI = 0.547-0.971, p = 0.031). Meta-analysis revealed an association between vasculitis and the IL-10-819 C allele (OR = 0.804, 95% CI = 0.706-0.916, p = 0.001) in all study subjects and Behcet's disease (BD) (OR = 0.724, 95% CI = 0.679-0.781, p < 1.0 × 10(-9)). Meta-analysis of the IL-10-592 C allele showed an association with vasculitis in all study subjects (OR = 0.805, 95% CI = 0.619-0.938, p = 0.005) and BD (OR = 0.718, 95% CI = 0.661-0.781, p < 1.0 × 10(-9)). Meta-analysis of the IL-10 haplotype revealed an association between the GCC haplotype and vasculitis in Europeans (OR = 1.239, 95% CI = 1.105-1.513, p = 0.035). CONCLUSIONS: This meta-analysis showed that IL-10 polymorphisms are associated with vasculitis susceptibility, especially in WG and BD. |
| File Format | HTM / HTML |
| ISSN | 08820139 |
| Issue Number | 6 |
| Journal | Immunological Investigations |
| Volume Number | 44 |
| e-ISSN | 15324311 |
| Language | English |
| Publisher | Taylor & Francis |
| Publisher Date | 2015-01-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Immunology Genetic Predisposition To Disease Interleukin-10 Genetics Vasculitis Humans Polymorphism, Genetic Journal Article Meta-analysis |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine Immunology |
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