NDLI: Functional Promoter Polymorphisms of MMP-2 C-735T and MMP-9 C-1562T and Their Synergism with MMP-7 A-181G in Multiple Sclerosis.

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Functional Promoter Polymorphisms of MMP-2 C-735T and MMP-9 C-1562T and Their Synergism with MMP-7 A-181G in Multiple Sclerosis.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Rahimi, Zohreh Abdan, Zahra Rahimi, Ziba Razazian, Nazanin Shiri, Hadis Vaisi-Raygani, Asad Shakiba, Ebrahim Vessal, Mahmood Moradi, Mohammad-Taher
Description	Country affiliation: Iran Author Affiliation: Rahimi Z ( a Medical Biology Research Center , Kermanshah University of Medical Sciences , Kermanshah , Iran.); Abdan Z ( b Department of Biochemistry , Medical School, Kermanshah University of Medical Sciences , Kermanshah , Iran.); Rahimi Z ( c Department of Biology , Science and Research Branch, Islamic Azad University , Tehran , Iran.); Razazian N ( a Medical Biology Research Center , Kermanshah University of Medical Sciences , Kermanshah , Iran.); Shiri H ( d Department of Neurology , Medical School, Kermanshah University of Medical Sciences , Kermanshah , Iran.); Vaisi-Raygani A ( e Department of Biochemistry , Fars Science and Research Branch, Islamic Azad University , Fars , Iran.); Shakiba E ( f Fertility and Infertility Research Center , Kermanshah University of Medical Sciences , Kermanshah , Iran.); Vessal M ( b Department of Biochemistry , Medical School, Kermanshah University of Medical Sciences , Kermanshah , Iran.); Moradi MT ( e Department of Biochemistry , Fars Science and Research Branch, Islamic Azad University , Fars , Iran.)
Abstract	Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system. Matrix metalloproteinases (MMPs) play an important role in breakdown of blood-brain barrier, transmigration, and invasion of immune cells and formation of MS lesions. The aim of present study was to investigate the influence of MMP-2 C-735T and MMP-9 C-1562T variants and their synergism with MMP-7 A-181G on susceptibility to MS. In a case-control study 125 MS patients and 235 healthy individuals from Western Iran were investigated. The various genotypes of MMP-2, MMP-9, and MMP-7 were detected using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). In females the presence of MMP-2 C allele was associated with an increased risk of MS (OR = 1.69, p = 0.041). No significant difference was detected between the frequency of MMP-9 T allele in MS patients (8.2%) and controls (12.8%, p = 0.068). The concomitant presence of both MMP-2 C and MMP-7 G alleles was associated with 1.82-fold increased risk of MS (p = 0.002). Also, a synergism was detected between MMP-9 C and MMP-7 G alleles that elevated the risk of MS by 1.5-times (p = 0.035). The presence of haplotype MMP-9 T, MMP-7 G, and MMP-2 C (TGC) compared to haplotype CAG increased the risk of MS by 3.13-fold (p = 0.16). The present study suggests that gene-gene interactions and variants of more genes instead of single gene might play a role in susceptibility to MS. We indicated that synergism between variants of MMP-2, MMP-7, and MMP-9 genes might increase the risk of MS.
File Format	HTM / HTML
ISSN	08820139
Issue Number	6
Journal	Immunological Investigations
Volume Number	45
e-ISSN	15324311
Language	English
Publisher	Taylor & Francis
Publisher Date	2016-08-01
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Immunology
Content Type	Text
Resource Type	Article
Subject	Medicine Immunology

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