NDLI: Mirtazapine add-on therapy in the treatment of schizophrenia with atypical antipsychotics: a double-blind, randomised, placebo-controlled clinical trial.

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Mirtazapine add-on therapy in the treatment of schizophrenia with atypical antipsychotics: a double-blind, randomised, placebo-controlled clinical trial.

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Mirtazapine add-on therapy in the treatment of schizophrenia with atypical antipsychotics: a double-blind, randomised, placebo-controlled clinical trial.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Berk, Michael Gama, Clarissa S. Sundram, Suresh Hustig, Harry Koopowitz, Les D'Souza, Russell Malloy, Hamish Rowland, Cate Monkhouse, Alison Monkhouse, Andrew Bole, Fiona Sathiyamoorthy, Sumathy Piskulic, Danijela Dodd, Seetal
Description	Country affiliation: Australia Author Affiliation: Berk M ( Department of Clinical and Biomedical Sciences: Barwon Health, The University of Melbourne, Geelong, Australia.)
Abstract	OBJECTIVE: Schizophrenia is a multifaceted illness with positive, negative and cognitive symptom domains. Standard treatments often focus on positive symptoms and may not adequately relieve other symptoms. Previous studies have suggested a role for mirtazapine in schizophrenia, particularly in negative symptoms. This study investigates the efficacy of adding mirtazapine to treatment as usual to alleviate the negative symptoms of schizophrenia. METHODS: In a 6 week, double-blind clinical trial, participants with a diagnosis of schizophrenia and currently being treated with atypical antipsychotic medication were randomised to adjunctive treatment with mirtazapine (30 mg/day) or placebo. The primary outcome measure was improvement in the Positive and Negative Syndrome Scale (PANSS). Measures of cognition, collected at baseline and week 6 only, were analysed using an Analysis of Covariance (ANCOVA) model. All other outcome measures were analysed using a linear mixed model. RESULTS: Forty participants were recruited to the study with equal numbers randomised to each treatment arm. There was no significant difference between mirtazapine and placebo treated participants for improvement in PANSS scores or any of the secondary outcome measures at any stage during the 6-week trial. CONCLUSIONS: This trial does not confirm previous research supporting the use of mirtazapine adjunctive to atypical antipsychotic treatment for schizophrenia.
File Format	HTM / HTML
ISSN	08856222
Issue Number	3
Volume Number	24
e-ISSN	10991077
Journal	Human Psychopharmacology: Clinical and Experimental
Language	English
Publisher	Wiley
Publisher Date	2009-04-01
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Psychopharmacology Antidepressive Agents, Tricyclic Therapeutic Use Antipsychotic Agents Mianserin Analogs & Derivatives Schizophrenia Drug Therapy Physiopathology Adult Double-blind Method Drug Therapy, Combination Female Humans Male Middle Aged Psychiatric Status Rating Scales Treatment Outcome Journal Article Randomized Controlled Trial Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Neurology Neurology (clinical) Pharmacology (medical) Psychiatry and Mental Health

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