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Year: 2010 Volume: 24 Issue: Supplementary 1

Year: 2009 Volume: 23

Year: 2008 Volume: 22

Combined therapy in the treatment of hypertension.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Escobar, Carlos Barrios, Vivencio
Spatial Coverage	Europe
Description	Country affiliation: Spain Author Affiliation: Escobar C ( Department of Cardiology, Hospital Infanta Sofia, Madrid, Spain.)
Abstract	The majority of patients with hypertension need at least two antihypertensive agents to achieve blood pressure (BP) objectives. As current European guidelines for the treatment of arterial hypertension recommend, combined therapy is required when monotherapy fails and as a first-line treatment in certain situations, such as subjects at high or very high cardiovascular risk, markedly elevated BP values, or when lower targets are required (<130/80 mmHg). The advantages of combined therapy are well known and include an earlier and higher antihypertensive efficacy because of complementary mechanisms of action, and a lower incidence of side effects due to the possible compensatory responses and, in many cases, the lower doses used. In the present study, available evidence about the efficacy and tolerability of combined therapy for the treatment of hypertension is updated.
File Format	HTM / HTML
ISSN	07673981
Issue Number	1
Volume Number	24
e-ISSN	14728206
Journal	Fundamental & Clinical Pharmacology
Language	English
Publisher	Wiley
Publisher Date	2010-02-01
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Pharmacology Antihypertensive Agents Therapeutic Use Blood Pressure Drug Effects Hypertension Drug Therapy Administration & Dosage Adverse Effects Cardiovascular Diseases Etiology Prevention & Control Drug Therapy, Combination Europe Humans Complications Practice Guidelines As Topic Risk Factors Treatment Outcome Journal Article Review
Content Type	Text
Resource Type	Article
Subject	Pharmacology Pharmacology (medical)

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