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Incidence of hospital admissions due to adverse drug reactions in France: the EMIR study.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Bénard-Laribière, Anne Miremont-Salamé, Ghada Pérault-Pochat, Marie-Christine Noize, Pernelle Haramburu, Françoise
Spatial Coverage	France
Description	Country affiliation: France Author Affiliation: Bénard-Laribière A ( CHU Bordeaux, Service de pharmacologie, F-33000, Bordeaux, France.)
Abstract	To assess the incidence of hospital admissions related to adverse drug reactions (ADRs) in France and the frequency of preventable ADRs in France, a prospective study was conducted among a representative randomly selected sample of medical wards in public hospitals between December 2006 and June 2007; all patients admitted during a 2-week period were included. An ADR-related hospitalization case was defined as a hospital admission because of an ADR, and an independent committee reviewed and validated all potential cases. Preventability was assessed using the French ADR preventability scale. Data were extrapolated to the population of France. Among 2692 admissions, 97 were related to an ADR (incidence 3.6%, 95% confidence interval, CI [2.8-4.4]). Patients admitted for an ADR were significantly older than those admitted for other reasons (P < 0.001). A third (32.0%) of ADR-related hospitalizations were 'preventable', 16.5% 'potentially preventable'. Drug interactions accounted for 29.9% of ADR-related hospitalizations. The most frequent causes of ADR-related hospitalizations were vascular disorders (20.6%), mainly bleeding complications, central nervous system disorders (11.3%), gastrointestinal disorders, and general disorders (9.3%). Antithrombotic and antineoplastic agents were the most frequently involved (12.6% each), followed by diuretics and analgesics (9.0% each). Vitamin-K-antagonists (VKAs) were the most common drugs associated with admission. The estimated annual number of ADR-related hospitalizations in France was 143 915 (95% CI [112 063-175 766]). ADRs were a significant cause of hospital admission in 2006-2007, in particular those due to VKAs. As new oral anticoagulants (NOACs) have been marketed, more attention needs to be paid to ensure a safe use of antithrombotic agents.
File Format	HTM / HTML
ISSN	07673981
Issue Number	1
Volume Number	29
e-ISSN	14728206
Journal	Fundamental & Clinical Pharmacology
Language	English
Publisher	Wiley
Publisher Date	2015-02-01
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Pharmacology Drug-related Side Effects And Adverse Reactions Epidemiology Adolescent Adult Adverse Drug Reaction Reporting Systems Aged Anticoagulants Adverse Effects Drug Interactions Etiology France Hospitalization Humans Incidence Middle Aged Prospective Studies Young Adult Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Pharmacology Pharmacology (medical)

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