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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Wauters, Isabelle Vansteenkiste, Johan |
| Description | Country affiliation: Belgium Author Affiliation: Wauters I ( Respiratory Oncology Unit (Pulmonology) and Leuven Lung Cancer Group, University Hospital Gasthuisberg, Catholic University, Leuven, Belgium.) |
| Abstract | Chemotherapy-induced anemia (CIA) is a frequent problem in cancer patients with a negative impact on prognosis and quality of life. Erythropoiesis-stimulating agents (ESAs) have proven efficacy in improving hemoglobin levels and reducing red blood cell transfusion needs of these patients. In several randomized studies in settings other than CIA (such as patients not receiving any chemotherapy, or studies on preventive use of ESAs to keep high hemoglobin levels), safety signals that ESA therapy may result in worse cancer outcome were documented. We review the evidence for these safety concerns, the different hypotheses to explain effects on outcome, the implications of the more restrictive guidelines on ESA therapy on daily practice and possible alternative treatments to consider. |
| File Format | HTM / HTML |
| ISSN | 17512433 |
| Issue Number | 4 |
| Volume Number | 4 |
| e-ISSN | 17512441 |
| Journal | Expert Review of Clinical Pharmacology |
| Language | English |
| Publisher | Taylor & Francis |
| Publisher Date | 2011-07-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Pharmacology Anemia Drug Therapy Antineoplastic Agents Adverse Effects Hematinics Therapeutic Use Neoplasms Blood Chemically Induced Animals Humans Randomized Controlled Trials As Topic Methods Journal Article Review |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pharmacology, Toxicology and Pharmaceutics Pharmacology (medical) |
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