NDLI: Co-administration of quercetin with pantoprazole sodium prevents NSAID-induced severe gastroenteropathic damage efficiently: Evidence from a preclinical study in rats.

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Year: 2017 Volume: 69

Year: 2017 Volume: 69 Issue: 3

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Co-administration of quercetin with pantoprazole sodium prevents NSAID-induced severe gastroenteropathic damage efficiently: Evidence from a preclinical study in rats.

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Co-administration of quercetin with pantoprazole sodium prevents NSAID-induced severe gastroenteropathic damage efficiently: Evidence from a preclinical study in rats.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Singh, Devendra Pratap Borse, Swapnil P. Nivsarkar, Manish
Description	Country affiliation: India Author Affiliation: Singh DP ( Department of Pharmacology and Toxicology, B.V. Patel Pharmaceutical Education and Research Development (PERD) Centre, Thaltej, Ahmedabad, Gujarat 380054, India); Borse SP ( Department of Pharmacology and Toxicology, B.V. Patel Pharmaceutical Education and Research Development (PERD) Centre, Thaltej, Ahmedabad, Gujarat 380054, India); Nivsarkar M ( Department of Pharmacology and Toxicology, B.V. Patel Pharmaceutical Education and Research Development (PERD) Centre, Thaltej, Ahmedabad, Gujarat 380054, India. Electronic address: manishnivsarkar@gmail.com.)
Abstract	Management of Nonsteroidal anti-inflammatory drug (NSAID)-induced gastroenteropathy has emerged as a major medical and socioeconomic problem mainly because the highly efficacious gastroprotective drugs i.e. proton pump inhibitors (PPIs) like pantoprazole sodium (PTZ), worsen the NSAID-induced enteropathic damage and lack of approved therapeutic strategies/interventions to prevent this damage. Hence, the primary objective of the current study was to assess whether we can protect the GI mucosa against gastroenteropathic damage caused by diclofenac sodium (DIC) in rats by co-administration of PTZ and quercetin (QCT). Rats were treated twice daily with QCT (35, 50 and 100mgkg peroral) and/or PTZ (4mgkg ) or vehicle for a total of 10 days. In some experiments, DIC (9mgkg ) was administered orally twice daily for the final 5days of PTZ/QCT+PTZ/vehicle administration. Rats in all the groups were fasted after the last dose on 9th day, but, water was provided ad libitum. 12h after the last dose on 10th day, rats were euthanized and their GI tracts were assessed for haemorrhagic damage, lipid peroxidation, intestinal permeability and GI luminal pH alterations along with haematological and biochemical estimations. The experimental evidences suggested that co-administration of QCT with PTZ significantly attenuated the exacerbation of NSAID-induced enteropathic damage in a dose dependent manner. The combination of PTZ 4mgkg and QCT at the doses of 50 or 100mgkg was found to effective in preventing the DIC-induced gastroenteropathy. The present report focuses on the gastroenteroprotective ability of QCT and the mechanisms may be related to its ability to prevent GI blood loss, the lipid peroxidation, intestinal permeability alteration and alteration in GI luminal pH.
File Format	HTM / HTML
ISSN	09402993
Issue Number	1
Volume Number	69
e-ISSN	16181433
Journal	Experimental and Toxicologic Pathology
Language	English
Publisher	Elsevier
Publisher Date	2017-01-01
Publisher Place	Germany
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Toxicology Discipline Pathology 2-pyridinylmethylsulfinylbenzimidazoles Pharmacology Anti-inflammatory Agents, Non-steroidal Toxicity Gastric Mucosa Drug Effects Intestinal Mucosa Quercetin Animals Antioxidants Diclofenac Pathology Lipid Peroxidation Male Proton Pump Inhibitors Rats Rats, Wistar Journal Article
Content Type	Text
Resource Type	Article
Subject	Cell Biology Toxicology Pathology and Forensic Medicine

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