NDLI: Pro-oxidant-antioxidant balance in Iranian veterans with sulfur mustard toxicity and different levels of pulmonary disorders.

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Pro-oxidant-antioxidant balance in Iranian veterans with sulfur mustard toxicity and different levels of pulmonary disorders.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Nobakht M. Gh, B. Fatemeh Oskouie, Afsaneh Arefi Aliannejad, Rasoul Rezaei-Tavirani, Mostafa Tavallaie, Shima Baghban, Alireza Akbarzadeh Taheri, Salman Keramati, Mohammad Reza Alamdari, Daryoush Hamidi
Description	Country affiliation: Iran Author Affiliation: Nobakht M Gh BF ( a Proteomics Research Center, Shahid Beheshti University of Medical Sciences , Tehran , Iran .); Oskouie AA ( b Department of Basic Sciences, Faculty of Paramedical Sciences , Shahid Beheshti University of Medical Sciences , Tehran , Iran .); Aliannejad R ( b Department of Basic Sciences, Faculty of Paramedical Sciences , Shahid Beheshti University of Medical Sciences , Tehran , Iran .); Rezaei-Tavirani M ( c Pulmonary Department , Shariati Hospital, Tehran University of Medical Sciences , Tehran , Iran .); Tavallaie S ( a Proteomics Research Center, Shahid Beheshti University of Medical Sciences , Tehran , Iran .); Baghban AA ( d Department of Biochemistry, Faculty of Medicine , Mashhad University of Medical Sciences , Mashhad , Iran .); Taheri S ( e Department of Basic Sciences , School of Rehabilitation, Shahid Beheshti University of Medical Sciences , Tehran , Iran .); Keramati MR ( f Chemistry and Chemical Engineering Research Center of Iran , Tehran , Iran .); Alamdari DH ( g Faculty of Medicine , Cancer Molecular Pathology Research Center, Mashhad University of Medical Sciences , Mashhad , Iran , and.)
Abstract	OBJECTIVE: Sulfur mustard (SM) is a strong alkylating agent that primarily targets the skin, eye and lung. The current study evaluated the pro-oxidant-antioxidant balance (PAB) assay in human serum of SM-exposed patients. DESIGN AND METHODS: sera of 35 SM-exposed patients and 19 healthy volunteers were recruited. Both groups had nonsmoker and nonalcoholic people with no diseases such as diabetes, heart disease and other pulmonary diseases (COPD because of smoking, asthma and so on). All patients had documented exposure to SM. The PAB was measured. RESULTS: SM-exposed patients with normal values for pulmonary function test and severe obstructive pulmonary disease demonstrated a significant increase in PAB value in compared with healthy volunteers (the PAB values in healthy volunteers, normal and severe patients were 48.74 ± 21.07 HK, 101.45 ± 32.68 HK and 120.23 ± 31.55 HK, respectively). However, the level of oxidation is not related to the severity of disease defined by spirometry findings. A significant negative correlation was established between the PAB value and FEV1. CONCLUSIONS: The increased PAB value in chemical casualties showed that these patients are exposed to oxidative stress.
File Format	HTM / HTML
ISSN	01480545
Issue Number	4
Journal	Drug and Chemical Toxicology
Volume Number	39
e-ISSN	15256014
Language	English
Publisher	Taylor & Francis
Publisher Date	2016-10-01
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Toxicology
Content Type	Text
Resource Type	Article
Subject	Health, Toxicology and Mutagenesis Public Health, Environmental and Occupational Health Toxicology Pharmacology Chemical Health and Safety

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