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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Shilova, O. N. Souslova, E. A. Pilunov, A. M. Deyev, S. M. Petrov, R. V. |
| Description | Country affiliation: RUSSIA Author Affiliation: Shilova ON ( Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, 117997, Russia. olga.shilova.n@gmail.com.); Souslova EA ( Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, 117997, Russia.); Pilunov AM ( Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, 117997, Russia.); Deyev SM ( Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, 117997, Russia.); Petrov RV ( Nizhny Novgorod State University, Nizhny Novgorod, 603600, Russia.) |
| Abstract | Development of agents for theranostics implies combining the targeting module, the effector module, and the detection module within the same complex or recombinant protein. We have constructed, isolated, and characterized the 4D5scFv-mCherry-PE(40) protein, which exhibits fluorescent properties and specifically binds to cancer cells expressing the HER2 receptor and reduces their viability. The ability of the obtained targeted antitumor agent 4D5scFv-mCherry-PE(40) to selectively stain the HER2-positive cells and its highly selective cytotoxicity against these cells make the obtained targeted recombinant protein 4D5scFv-mCherry-PE(40) a promising theranostic agent for the diagnostics and therapy of HER2-positive human tumors. |
| File Format | HTM / HTML |
| ISSN | 16076729 |
| Issue Number | 1 |
| Volume Number | 471 |
| e-ISSN | 16083091 |
| Journal | Doklady Biochemistry and Biophysics |
| Language | English |
| Publisher | Springer |
| Publisher Date | 2016-11-01 |
| Publisher Place | Russian Federation |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Biophysics Discipline Biochemistry Immunotoxins Pharmacology Luminescent Proteins Single-chain Antibodies Animals Antineoplastic Agents Chemical Synthesis Isolation & Purification Toxicity Cho Cells Cell Line, Tumor Cell Survival Drug Effects Chromatography, Affinity Cricetulus Escherichia Coli Fluorescence Genetic Vectors Humans Microscopy, Fluorescence Receptor, Erbb-2 Metabolism Recombinant Proteins Journal Article |
| Content Type | Text |
| Resource Type | Article |
| Subject | Chemistry Medicine Biochemistry Biophysics |
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