NDLI: Cloning and expression of medaka cholesterol side chain cleavage cytochrome P450 during gonadal development.

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Cloning and expression of medaka cholesterol side chain cleavage cytochrome P450 during gonadal development.

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Cloning and expression of medaka cholesterol side chain cleavage cytochrome P450 during gonadal development.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Nakamoto, Masatoshi Fukasawa, Motoaki Orii, Shinya Shimamori, Kazusuke Maeda, Takafumi Suzuki, Aya Matsuda, Masaru Kobayashi, Tohru Nagahama, Yoshitaka Shibata, Naoki
Description	Country affiliation: Japan Author Affiliation: Nakamoto M ( Department of Biology, Faculty of Science, Shinshu University, Matsumoto, Nagano, Japan.)
Abstract	Cholesterol side chain cleavage cytochrome P450 (P450scc, Cyp11a) is responsible for the first step in steroidogenesis, catalyzing the conversion of cholesterol to prognenolone. To investigate the differentiation of steroid-producing cells and the function of sex steroids during gonadal differentiation in the teleost fish, medaka (Oryzias latipes), we isolated the full length cDNA of medaka P450scc and analyzed the expression pattern of P450scc mRNA during gonadal development using in situ hybridization. At hatching, and just after the initiation of morphological sex differentiation, we did not detect any P450scc expression in both sexes. In male gonads, expression of P450scc was detected in the interstitial somatic cells 15 days after hatching following the formation of the seminiferous tubule precursor, and was maintained in the interstitial somatic cells throughout testicular development. In the female gonad, expression of P450scc was initially detected in interstitial somatic cells 5 days after hatching. Subsequently, the expression of P450scc was continuously detected in the interstitial somatic cells of the developing ovary. This expression pattern of P450scc differed from that of female specific steroidogenic enzyme P450arom. Both P450scc and P450arom expressing cells, only P450scc expressing cells, and only P450arom expressing cells were observed. Our results suggest that expression of steroidogenic enzymes is regulated by various mechanisms during ovarian development.
File Format	HTM / HTML
ISSN	00121592
Issue Number	4
Volume Number	52
e-ISSN	1440169X
Journal	Development, Growth & Differentiation
Language	English
Publisher	Wiley-Blackwell
Publisher Date	2010-05-01
Publisher Place	Japan
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Embryology Discipline Biology Cholesterol Side-chain Cleavage Enzyme Genetics Fish Proteins Gene Expression Profiling Gonads Metabolism Oryzias Amino Acid Sequence Animals Cloning, Molecular Dna, Complementary Chemistry Female Gene Expression Regulation, Developmental Gene Expression Regulation, Enzymologic Enzymology Growth & Development In Situ Hybridization Male Molecular Sequence Data Ovary Reverse Transcriptase Polymerase Chain Reaction Sequence Analysis, Dna Sequence Homology, Amino Acid Sex Differentiation Testis Journal Article
Content Type	Text
Resource Type	Article
Subject	Cell Biology Developmental Biology Medicine

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