NDLI: A paired comparison between human skin and hairless guinea pig skin in vitro permeability and lag time measurements for 6 industrial chemicals.

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A paired comparison between human skin and hairless guinea pig skin in vitro permeability and lag time measurements for 6 industrial chemicals.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Frasch, H. Frederick Barbero, Ana M.
Description	Country affiliation: United States Author Affiliation: Frasch HF ( Exposure Assessment Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26508, USA. hfrasch@cdc.gov)
Abstract	The purpose of the present study was to measure and compare permeability coefficients (k(p)) and lag times (tau) in human skin and hairless guinea pig (HGP) skin. Paired experiments employed heat-separated epidermal membranes from human and HGP sources mounted on static in vitro diffusion cells. Infinite-dose, saturated aqueous solutions of 6 industrial chemicals were used as donors: aniline, benzene, 1,2- dichloroethane, diethyl phthalate, naphthalene, and tetrachloroethylene. No significant differences were found between human and HGP skin for either k(p) or tau for any of these chemicals (p >or= .24). HGP vs. human k(p) measurements, and HGP vs. human tau measurements, were highly correlated. For k(p), the slope of the linear correlation was close to unity (1.080 +/- 0.182) and the intercept close to 0 (0.015 +/- 0. 029 cm/h), with a correlation coefficient (r(2)) = 0.898. For tau, the slope was also close to unity (0.818 +/- 0.030) and the intercept close to 0 (-0.014 +/- 0.023 h), with r(2) = 0.994. These results suggest that HGP skin may serve as an excellent surrogate for human skin in in vitro dermal penetration studies.
File Format	HTM / HTML
ISSN	15569527
Issue Number	3
Volume Number	28
e-ISSN	15569535
Journal	Cutaneous and Ocular Toxicology
Language	English
Publisher	Taylor & Francis
Publisher Date	2009-01-01
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Ophthalmology Discipline Toxicology Discipline Dermatology Hazardous Substances Toxicity Skin Absorption Drug Effects Skin Adult Animals Chromatography, Gas Diffusion Chambers, Culture Female Guinea Pigs Humans In Vitro Techniques Industry Male Middle Aged Molecular Structure Risk Assessment Metabolism Time Factors Toxicity Tests Methods Standards Young Adult Comparative Study Journal Article Research Support, U.s. Gov't, P.h.s.
Content Type	Text
Resource Type	Article
Subject	Medicine Toxicology

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