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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Tamjidipoor, Ahmad Tavafi, Majid Ahmadvand, Hasan |
| Description | Author Affiliation: Tamjidipoor A ( Razi Herbal Medicines Research Center, Lorestan University of Medical Sciences , Khorramabad , Iran and.) |
| Abstract | There is increasing evidence that oxidative stress, due to estrogen deficiency, leads to osteopenia. In this study, dimethyl sulfoxide (DMSO), an antioxidant solvent, was used against post-ovariectomy osteopenia (PO) in rats. Forty female rats were divided into 5 groups randomly as follows: Sham, control group; OVX, ovariectomized group; DMSO1, ovariectomized injected DMSO (0.5 ml/kg/d ip); DMSO2, ovariectomized injected DMSO (1 ml/kg/day ip) and DMSO3, ovariectomized injected DMSO (2 ml/kg/d ip). DMSO therapy started 1 week after ovariectomy and continued for 13 weeks. After 13th weeks, sera were prepared, and then L4 vertebrae and right tibial bones rinsed in fixative. Serum bone alkaline phosphatase (BALP), osteocalcin, pyridinoline, malondialdehyde (MDA) and glutathione (GSH) were measured. Trabecular volume density, trabecular and cortex thickness were estimated. Osteoclast and osteoblast numbers were counted morphometrically. The data were analyzed by ANOVA and then post hoc Tukey test at p < 0.05. The increase of pyridinoline and decrease of BALP in DMSO injected groups were inhibited compared with OVX group (p < 0.05). In DMSO injected groups, decrease of bone density, trabecular volume density, thickness of trabecular and tibial cortex were inhibited compared with OVX group (p < 0.05). MDA decreased significantly in DMSO injected groups compared with OVX group. Osteoclast number decreased in DMSO injected groups compared with OVX group (p < 0.05). Osteoblast number did not show significant change in DMSO groups compared with OVX group. In conclusion, DMSO ameliorates PO through decrease of osteoclast number, osteoclast inhibition and osteoblast activation. These effects may probably be mediated via antioxidant property of DMSO. |
| File Format | HTM / HTML |
| ISSN | 03008207 |
| Issue Number | 6 |
| Volume Number | 54 |
| e-ISSN | 16078438 |
| Journal | Connective Tissue Research |
| Language | English |
| Publisher | Taylor & Francis |
| Publisher Date | 2013-01-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Rheumatology Bone Diseases, Metabolic Drug Therapy Etiology Dimethyl Sulfoxide Therapeutic Use Ovariectomy Adverse Effects Alkaline Phosphatase Blood Amino Acids Animals Bone Density Drug Effects Pathology Cell Count Pharmacology Female Glutathione Malondialdehyde Organ Size Osteoblasts Osteocalcin Osteoclasts Rats Rats, Sprague-dawley Tibia Enzymology Journal Article |
| Content Type | Text |
| Resource Type | Article |
| Subject | Orthopedics and Sports Medicine Cell Biology Molecular Biology Biochemistry Rheumatology |
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