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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Koteswara Reddy, G. Nagamalleswara Rao, K. Yarrakula, Kiran |
| Description | Author Affiliation: Koteswara Reddy G ( Centre for Disaster Mitigation and Management, VIT University, Vellore-632014, India. Electronic address: kotireddy.nit@gmail.com.); Nagamalleswara Rao K ( School of Civil and Chemical Engineering, VIT University, Vellore-632014, India.); Yarrakula K ( Centre for Disaster Mitigation and Management, VIT University, Vellore-632014, India.) |
| Abstract | The gene 30S ribosomal protein S2 (30S2) is identified as a potential drug and vaccine target for Pneumonia. Its structural characterization is an important to understand the mechanism of action for identifying its receptor and/or other binding partners. The comparative genomics and proteomics studies are useful for structural characterization of 30S2 in C. Pneumoniae using different bioinformatics tools and web servers. In this study, the protein 30S2 structure was modelled and validated by Ramachandran plot. It is found that the modelled protein under most favoured 'core' region was 88.7% and overall G-factor statistics with average score was -0.20. However, seven sequential motifs have been identified for 30S2 with reference codes (PR0095, PF0038, TIGR01012, PTHR11489, SSF52313 and PTHR11489). In addition, seven structural highly conserved residues have been identified in the large cleft are Lys160, Gly161and Arg162 with volume 1288.83Å and average depth of the cleft was 10.75Å. Moreover, biological functions, biochemical process and structural constituents of ribosome are also explored. The study will be helped us to understand the sequential, structural, functional and evolutionary clues of unknown proteins available in C. Pneumoniae. |
| File Format | HTM / HTML |
| ISSN | 14769271 |
| Journal | Computational Biology and Chemistry |
| Volume Number | 66 |
| e-ISSN | 1476928X |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2016-11-09 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Medical Informatics Discipline Chemistry Discipline Computational Biology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Organic Chemistry Structural Biology Biochemistry Computational Mathematics |
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