NDLI: An enigmatic tail of CD28 signaling.

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An enigmatic tail of CD28 signaling.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Boomer, Jonathan S. Green, Jonathan M.
Description	Country affiliation: United States Author Affiliation: Boomer JS ( Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA.)
Abstract	CD28 costimulation regulates a wide range of cellular processes, from proliferation and survival to promoting the differentiation of specialized T-cell subsets. Since first being identified over 20 years ago, CD28 has remained a subject of intense study because of its profound consequences on T cell function and its potential for therapeutic manipulation. In this review we highlight the signaling cascades initiated by the major signaling motifs in CD28, focusing on PI-3 kinase-dependent and -independent pathways and how these are linked to specific cellular outcomes. Recent studies using gene targeted knockin mice have clarified the relative importance of these motifs on in vivo immune responses; however, much remains to be elucidated. Understanding the mechanism behind costimulation holds great potential for development of new clinically relevant reagents, a fact beginning to be realized with the advent of drugs that prevent CD28 ligation and signaling.
File Format	HTM / HTML
e-ISSN	19430264
DOI	10.1101/cshperspect.a002436
Journal	Cold Spring Harbor Perspectives in Biology
Issue Number	8
Volume Number	2
Language	English
Publisher	Cold Spring Harbor Laboratory Press
Publisher Date	2010-08-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline Biology Antigens, Cd28 Chemistry T-lymphocytes Metabolism Amino Acid Motifs Animals Cell Line Immune System Lymphocyte Activation Mice Mice, Transgenic Models, Biological Phosphatidylinositol 3-kinases Protein Interaction Mapping Receptors, Antigen, T-cell Signal Transduction Research Support, N.i.h., Extramural
Content Type	Text
Resource Type	Article

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
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8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Signals and sequences that control CD28 localization to the central region of the immunological synapse.

CD28 promotes CD4+ T cell clonal expansion during infection independently of its YMNM and PYAP motifs.

CD8 T cell competition for dendritic cells in vivo is an early event in activation.

IL-18 synergizes with IL-7 to drive slow proliferation of naive CD8 T cells by costimulating self-peptide-mediated TCR signals.

LFA-1-dependent $Ca^{2+}$ Entry following Suboptimal T Cell Receptor Triggering Proceeds without Mobilization of Intracellular $Ca^{2+}$

Costimulation of IL-2 Production through CD28 Is Dependent on the Size of Its Ligand.

Induction of B-cell immune tolerance by antigen-modified cytotoxic T lymphocytes.

Molecular mechanisms of T cell co-stimulation and co-inhibition.

Murine regulatory T cells contain hyperproliferative and death-prone subsets with differential ICOS expression.

An enigmatic tail of CD28 signaling.

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Signals and sequences that control CD28 localization to the central region of the immunological synapse.

CD28 promotes CD4+ T cell clonal expansion during infection independently of its YMNM and PYAP motifs.

CD8 T cell competition for dendritic cells in vivo is an early event in activation.

IL-18 synergizes with IL-7 to drive slow proliferation of naive CD8 T cells by costimulating self-peptide-mediated TCR signals.

LFA-1-dependent $Ca^{2+}$ Entry following Suboptimal T Cell Receptor Triggering Proceeds without Mobilization of Intracellular $Ca^{2+}$

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An enigmatic tail of CD28 signaling.