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Cerebral perfusion information obtained by dynamic contrast-enhanced phase-shift magnetic resonance imaging: comparison with model-free arterial spin labelling.

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Cerebral perfusion information obtained by dynamic contrast-enhanced phase-shift magnetic resonance imaging: comparison with model-free arterial spin labelling.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Wirestam, Ronnie Lindgren, Emelie Van Westen, Danielle Bloch, Karin Markenroth Ståhlberg, Freddy Knutsson, Linda
Spatial Coverage	Sweden
Description	Country affiliation: Sweden Author Affiliation: Wirestam R ( Department of Medical Radiation Physics, Lund University, Lund, Sweden. ronnie.wirestam@med.lu.se)
Abstract	Phase-shift time curves following a bolus injection of gadolinium contrast agent were registered for grey-matter regions and large vessels in 14 subjects. Deconvolving a tissue phase-shift curve with a phase-based arterial input function resulted in a tissue residue function R(t). The peak value of R(t) provided a relative cerebral blood flow (CBF) index, while the area-to-height ratio of R(t) provided quantitative mean transit time (MTT). For comparison, quantitative CBF values in grey matter were acquired using model-free arterial spin labelling (ASL). The phase-based relative CBF estimates showed good linear correlation with ASL-based CBF (r = 0.82). Grey-matter MTT was 4.9 +/- 1.1 s (mean +/- SD).
File Format	HTM / HTML
ISSN	14750961
Issue Number	5
Volume Number	30
e-ISSN	1475097X
Journal	Clinical Physiology and Functional Imaging
Language	English
Publisher	Wiley-Blackwell
Publisher Date	2010-09-01
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Physiology Discipline Pathology Cerebrovascular Circulation Contrast Media Magnetic Resonance Imaging Meglumine Organometallic Compounds Spin Labels Adult Aged Blood Flow Velocity Female Humans Image Interpretation, Computer-assisted Linear Models Male Middle Aged Models, Cardiovascular Predictive Value Of Tests Regional Blood Flow Sweden Time Factors Comparative Study Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Physiology Physiology (medical)

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