NDLI: Correlation of dosimetric and clinical factors with the development of esophagitis and radiation pneumonitis in patients with limited-stage small-cell lung carcinoma.

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Correlation of dosimetric and clinical factors with the development of esophagitis and radiation pneumonitis in patients with limited-stage small-cell lung carcinoma.

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Correlation of dosimetric and clinical factors with the development of esophagitis and radiation pneumonitis in patients with limited-stage small-cell lung carcinoma.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Giuliani, Meredith E. Lindsay, Patricia E. Kwan, Jennifer Y. Y. Sun, Alexander Bezjak, Andrea Le, Lisa W. Brade, Anthony Cho, John Leighl, Natasha B. Shepherd, Frances A. Hope, Andrew J.
Description	Author Affiliation: Giuliani ME ( Radiation Medicine Program, Princess Margaret Cancer Centre, Toronto, Ontario, Canada); Lindsay PE ( Radiation Medicine Program, Princess Margaret Cancer Centre, Toronto, Ontario, Canada); Kwan JY ( Radiation Medicine Program, Princess Margaret Cancer Centre, Toronto, Ontario, Canada); Sun A ( Radiation Medicine Program, Princess Margaret Cancer Centre, Toronto, Ontario, Canada); Bezjak A ( Radiation Medicine Program, Princess Margaret Cancer Centre, Toronto, Ontario, Canada); Le LW ( Department of Biostatistics, Princess Margaret Cancer Centre, Toronto, Ontario, Canada.); Brade A ( Radiation Medicine Program, Princess Margaret Cancer Centre, Toronto, Ontario, Canada); Cho J ( Radiation Medicine Program, Princess Margaret Cancer Centre, Toronto, Ontario, Canada); Leighl NB ( Department of Medical Oncology and Hematology, Princess Margaret Cancer Centre, Toronto, Ontario, Canada.); Shepherd FA ( Department of Medical Oncology and Hematology, Princess Margaret Cancer Centre, Toronto, Ontario, Canada.); Hope AJ ( Radiation Medicine Program, Princess Margaret Cancer Centre, Toronto, Ontario, Canada)
Abstract	BACKGROUND: The purpose of the study was to correlate clinical and dosimetric factors with the development of esophagitis and radiation pneumonitis in patients with limited-stage small-cell lung carcinoma (LS SCLC). PATIENTS AND METHODS: One hundred eighteen patients who received curative intent chemoradiotherapy for LS SCLC and had electronically archived radiation treatment plans were included. The medical charts were reviewed for clinical data. The treatment plan was reviewed for critical structure delineation and dose delivered. Treatment planning data were analyzed using Computational Environment for Radiotherapy Research (V3.3). Dosimetric parameters were correlated with the risk of toxicity using Spearman rank correlation. RESULTS: Radiotherapy dose was 40 Gy in 15 fractions (fx) (n = 80) and 45 Gy in 30 fractions twice per day (n = 38). The 6-month cumulative incidence of Grade ≥ 2 radiation pneumonitis was 6.5% and 7.9% for the 40 Gy/15 fx and 45 Gy/30 fx groups, respectively (P = .40). The 3-month cumulative incidence of Grade 3 esophagitis was 7.5% and 13.2% for the 40 Gy/15 fx and 45 Gy/30 fx groups, respectively (P = .31). Grade ≥ 3 pneumonitis was correlated with volume of lung receiving 20 Gy (V20) and mean lung dose. Grade ≥ 3 esophagitis was correlated with mean esophagus dose and minimum dose to the hottest 45% of the esophagus (D45). CONCLUSION: Mean lung dose and V20 were significant predictors of radiation pneumonitis in LS SCLC. Mean esophageal dose and D45 were significant predictors of esophagitis. These 2 treatment schedules have similar toxicity profiles.
File Format	HTM / HTML
ISSN	15257304
Issue Number	3
Volume Number	16
e-ISSN	19380690
Journal	Clinical Lung Cancer
Language	English
Publisher	Elsevier
Publisher Date	2015-05-01
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Pulmonary Medicine Discipline Oncology Chemoradiotherapy Adverse Effects Esophagitis Etiology Lung Neoplasms Radiotherapy Radiation Injuries Radiation Pneumonitis Small Cell Lung Carcinoma Adult Aged Aged, 80 And Over Epidemiology Female Follow-up Studies Humans Incidence Male Middle Aged Radiometry Retrospective Studies Survival Analysis Tomography, X-ray Computed Journal Article
Content Type	Text
Resource Type	Article
Subject	Pulmonary and Respiratory Medicine Cancer Research Oncology

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