NDLI: Minimizing wound contamination in a 'clean' surgery: comparison of chlorhexidine-ethanol and povidone-iodine.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Sistla, Sarath Chandra Prabhu, Ganesh Sistla, Sujatha Sadasivan, Jagdish
Description	Country affiliation: India Author Affiliation: Sistla SC ( Department of Surgery, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry, India. sarathsistla@hotmail.com)
Abstract	PURPOSE: There is limited work analyzing the efficacy of different antiseptics in reducing wound contamination by the skin flora during hernia repair and its influence on the incidence of wound infection, which continues to be a major problem in the developing world. This study was designed to test if chlorhexidine-ethanol has superior antimicrobial efficacy compared with povidone-iodine. METHODS: In a prospective randomized trial, the efficacy of chlorhexidine-ethanol and povidone-iodine in the reduction of colony counts of the skin flora and the incidence of surgical site infection was compared. RESULTS: Both povidone-iodine and chlorhexidine-ethanol produced significant reduction in the skin bacterial colony counts, from 18.66 x 10(2) to 2.34 x 10(2) colony-forming units with povidone-iodine (59%) and from 12.34 x 10(2) to 0.93 x 10(2) colony-forming units (82%) with chlorhexidine-ethanol. Infection rates with the use of povidone-iodine and chlorhexidine-ethanol groups were not significantly different (9.5 vs. 7.0; p = 0.364). The reduction in colony counts in those who developed infection was only 15.6% compared with 77.1% in those who did not develop infection. CONCLUSIONS: The antibacterial efficacy of chlorhexidine-ethanol and povidone-iodine is comparable in open hernia repair.
File Format	HTM / HTML
ISSN	00093157
Issue Number	4
Volume Number	56
e-ISSN	14219794
Journal	Chemotherapy
Language	English
Publisher	Karger
Publisher Date	2010-01-01
Publisher Place	Switzerland
Access Restriction	Subscribed
Subject Keyword	Discipline Therapeutics Discipline Pharmacology Anti-infective Agents, Local Therapeutic Use Chlorhexidine Ethanol Herniorrhaphy Povidone-iodine Skin Microbiology Surgical Wound Infection Prevention & Control Adult Administration & Dosage Colony Count, Microbial Female Hernia Complications Humans Male Middle Aged Comparative Study Journal Article Randomized Controlled Trial
Content Type	Text
Resource Type	Article
Subject	Infectious Diseases Drug Discovery Pharmacology Pharmacology (medical) Oncology

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