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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Imai, Hiroo Komine, Keigo Takahashi, Shin Saijo, Ken Okada, Yoshinari Kobayashi, Akihiro Okita, Akira Chikamatsu, Sonoko Kasahara, Yuki Takahashi, Masahiro Oishi, Takayuki Shirota, Hidekazu Takahashi, Masanobu Shimodaira, Hideki Ishioka, Chikashi |
| Abstract | BACKGROUND: Incomplete cross-resistances between paclitaxel (PTX) and docetaxel (DTX) has been demonstrated in several types of cancer. The objective of the present study was to assess the existence of cross-resistance between PTX and DTX in esophageal squamous cell carcinoma. METHODS: Patients in the PTX group received PTX without DTX pretreatment, patients in the prior DTX (Pr-DTX) group received PTX after the development of resistance to DTX, and patients in the DTX group received DTX without subsequent PTX treatment. RESULTS: A total of 73 patients were enrolled. The response rates to PTX in the PTX and Pr-DTX groups were 22.7 and 20.0%, respectively. The median progression-free survival times from the first day of PTX treatment in the PTX and Pr-DTX groups were 113 (95% CI 56-154) and 97 days (95% CI 36-189), respectively. The median overall survival times from the first day of DTX treatment in the Pr-DTX and DTX groups were 315 (95% CI 124-453) and 148 days (95% CI 139-177), respectively. CONCLUSIONS: There is no or incomplete clinical cross-resistance between PTX and DTX in esophageal squamous cell carcinoma. Replacement of DTX with PTX is a suitable treatment option for patients with DTX-resistant esophageal squamous cell carcinoma. |
| File Format | HTM / HTML |
| ISSN | 00093157 |
| Issue Number | 5 |
| Journal | Chemotherapy |
| Volume Number | 61 |
| e-ISSN | 14219794 |
| Language | English |
| Publisher | Karger |
| Publisher Date | 2016-01-01 |
| Publisher Place | Switzerland |
| Access Restriction | Subscribed |
| Subject Keyword | Discipline Therapeutics Discipline Pharmacology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Infectious Diseases Drug Discovery Pharmacology Pharmacology (medical) Oncology |
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