NDLI: Arsenic Trioxide Suppresses Paclitaxel-Induced Mitotic Arrest

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Arsenic Trioxide Suppresses Paclitaxel-Induced Mitotic Arrest

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Duan, Q. Komissarova, E. Dai, W.
Description	Country affiliation: China Author Affiliation: Duan Q ( Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China.)
Abstract	To human health, arsenic exhibits the property of a double-edged sword. Arsenic compounds such as $As_{2}O_{3}$ is effective for the treatment of relapsed/refractory acute promyelocytic leukemia, whereas chronic exposure to environmental arsenic is associated with the development of a variety of common cancers. Because $As_{2}O_{3}$ is capable of inhibiting tubulin polymerization and inducing mitotic arrest, we examined whether there existed any functional interaction between $As_{2}O_{3}$ and paclitaxel, a well-known microtubule poison. Flow cytometry and fluorescence microscopy revealed that although $As_{2}O_{3}$ alone caused a moderate level of mitotic arrest, it greatly attenuated paclitaxel-induced mitotic arrest in cells with p53 deficiency. Western blot analysis showed that $As_{2}O_{3}$ significantly blocked phosphorylation of BubR1, Cdc20, and Cdc27 in cells treated with paclitaxel, suggesting that arsenic compromised the activation of the spindle checkpoint. Our further studies revealed that the attenuation of paclitaxel-induced mitotic arrest by $As_{2}O_{3}$ resulted primarily from sluggish cell cycle progression at S phase but not enhanced mitotic exit. The clinical efficacy of taxol is associated with its ability to induce mitotic arrest and subsequent mitotic catastrophe. Our observations that $As_{2}O_{3}$ has a negative impact on the cell cycle checkpoint activation by taxol should have significant clinical implications.
File Format	HTM / HTML
ISSN	09607722
e-ISSN	13652184
DOI	10.1111/j.1365-2184.2009.00606.x
Journal	Cell Proliferation
Issue Number	3
Volume Number	42
Language	English
Publisher	Wiley
Publisher Date	2009-06-01
Publisher Place	Great Britain (UK)
Access Restriction	Open
Subject Keyword	Discipline Cytology Arsenicals Pharmacology Mitosis Drug Effects Oxides Paclitaxel Blotting, Western Cell Line Flow Cytometry Microscopy, Fluorescence Research Support, N.i.h., Extramural
Content Type	Text
Resource Type	Article
Subject	Cell Biology Medicine

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