NDLI: Correlation between hybrid capture II high-risk human papillomavirus DNA test chemiluminescence intensity from cervical samples with follow-up histologic results: a cytologic/histologic review of 367 cases.

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Correlation between hybrid capture II high-risk human papillomavirus DNA test chemiluminescence intensity from cervical samples with follow-up histologic results: a cytologic/histologic review of 367 cases.

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Correlation between hybrid capture II high-risk human papillomavirus DNA test chemiluminescence intensity from cervical samples with follow-up histologic results: a cytologic/histologic review of 367 cases.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Knoepp, Stewart M. Kuebler, Diane L. Wilbur, David C.
Description	Country affiliation: United States Author Affiliation: Knoepp SM ( Department of Pathology, University of Michigan, Ann Arbor, Michigan 48109, USA. sknoepp@umich.edu)
Abstract	BACKGROUND: The Hybrid Capture II high-risk human papillomavirus (hrHPV) DNA test is a US Food and Drug Administration-approved nucleic acid hybridization assay using chemiluminescence for the semiquantitative detection of hrHPV in cervical samples. Patient samples and controls are used to calculate results as negative for hrHPV if <1.0, positive for hrHPV if >2.5, and 'equivocal' if between 1.0 and 2.5. METHODS: The authors reported on the cervical histologic results of 209 patients demonstrating 'equivocal' results for hrHPV from SurePath (204 patients) or ThinPrep (5 patients) vials, and compared patients in this cohort with atypical squamous cells of undetermined significance (ASC-US) cytology on the index cervical Papanicolaou (Pap) test (Group 1; n = 148 patients) with a patient cohort demonstrating unequivocal positive hrHPV test results (Group 2; n = 148 patients). The chemiluminescence intensity of hrHPV tests from patients in Group 2 were correlated with the presence and severity of dysplasia on subsequent histologic results, and patients were thereby stratified for their subsequent risk of cervical intraepithelial neoplasia (CIN) types II/III. RESULTS: Approximately 97% of hrHPV tests demonstrating 'equivocal' results were found to be positive at the time of retesting, and 15% of biopsied cases demonstrated CIN II or III. Results of follow-up histology after an ASC-US diagnosis, expressed as a percentage of the biopsied cohort, were: CIN II/III: 16.5% in Group 1 and 22.4% in Group 2; CIN I: 27% in Group 1 and 23.5% in Group 2; and negative: 56.5% in Group 1 and 54.1% in Group 2. Chemiluminescence intensity did not appear to be correlated with the severity of dysplasia. CONCLUSIONS: The percentage of high-grade CIN in the 'equivocal' hrHPV cohort is highly significant and therefore the management of these patients should be similar to the unequivocally positive population. After an unequivocal positive hrHPV test, the hrHPV chemiluminescence intensity does not appear to further predict the rate of high-grade CIN.
File Format	HTM / HTML
ISSN	1934662X
Issue Number	4
Volume Number	118
e-ISSN	19346638
Journal	Cancer Cytopathology
Language	English
Publisher	Wiley-Blackwell
Publisher Date	2010-08-25
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Cytology Discipline Pathology Discipline Oncology Cervical Intraepithelial Neoplasia Pathology Virology Dna, Viral Isolation & Purification Luminescent Measurements Nucleic Acid Hybridization Methods Papillomaviridae Genetics Uterine Cervical Neoplasms Female Follow-up Studies Humans Risk Journal Article
Content Type	Text
Resource Type	Article
Subject	Cancer Research Oncology

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