NDLI: High concordance of EGFR mutation status between histologic and corresponding cytologic specimens of lung adenocarcinomas.

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High concordance of EGFR mutation status between histologic and corresponding cytologic specimens of lung adenocarcinomas.

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High concordance of EGFR mutation status between histologic and corresponding cytologic specimens of lung adenocarcinomas.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Sun, Ping-Li Jin, Yan Kim, Hyojin Lee, Choon-Taek Jheon, Sanghoon Chung, Jin-Haeng
Description	Author Affiliation: Sun PL ( Department of Pathology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Republic of Korea.)
Abstract	BACKGROUND: Activating mutations in the epidermal growth factor receptor (EGFR) in non-small cell lung carcinoma (NSCLC) are associated significantly with responsiveness to EGFR tyrosine kinase inhibitors. The objective of this study was to investigate the suitability of cytologic specimens for assessing EGFR mutations in lung adenocarcinomas. METHODS: Sixty paired histologic and cytologic specimens of lung adenocarcinoma were collected. Exons 18 through 21 of the EGFR gene were amplified using polymerase chain reaction, and the mutation status of each sample was analyzed by pyrosequencing. A comparison of EGFR mutation status between histologic specimens and cytologic specimens was performed. RESULTS: The overall EGFR mutation concordance rate between histologic specimens and corresponding cytologic specimens was 91.7%. No significant difference was observed in the concordance rate between cytologic specimens from primary lesions and specimens from metastatic lesions (P = .63). The following parameters were correlated with the most reliable EGFR mutation results using the pyrosequencing method (100% concordance with the corresponding histologic specimens) in cytologic samples: a DNA concentration >25 ng/µL, content of >30 tumor cells, or a tumor percentage >30%. CONCLUSIONS: In this study, routinely prepared cytologic specimens were reliable sources for assessing EGFR mutation status. The authors concluded that cytologic specimens from metastatic lesions and primary tumors are suitable for the successful assessment of EGFR mutation status.
File Format	HTM / HTML
ISSN	1934662X
Issue Number	6
Volume Number	121
e-ISSN	19346638
Journal	Cancer Cytopathology
Language	English
Publisher	Wiley-Blackwell
Publisher Date	2013-06-01
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Cytology Discipline Pathology Discipline Oncology Adenocarcinoma Diagnosis Carcinoma, Non-small-cell Lung Cytodiagnosis Lung Neoplasms Mutation Genetics Pleural Effusion Receptor, Epidermal Growth Factor Biopsy, Fine-needle Dna, Neoplasm Endoscopic Ultrasound-guided Fine Needle Aspiration Follow-up Studies Humans Neoplasm Metastasis Neoplasm Staging Polymerase Chain Reaction Prognosis Retrospective Studies Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Cancer Research Oncology

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