NDLI: Optimization of hepatocarcinoma uptake with radiolabeled lipiodol: development of new lipiodol formulations with increased viscosity.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Becker, Stéphanie Lepareur, Nicolas Cadeillan, Virginie Ardisson, Valérie Bayat, Sahar Noiret, Nicolas Garin, Etienne
Description	Country affiliation: France Author Affiliation: Becker S ( Centre Eugène Marquis, Nuclear Medicine Department, Rennes, France. stephanie.becker@rouen.fnclcc.fr)
Abstract	The aim of this study was to develop new Lipiodol formulations with increased viscosities to augment Lipiodol embolic effect and optimize efficiency of radiolabeled Lipiodol in hepatocarcinoma treatments. New Lipiodol formulations consist of Lipiodol mixtures with different stearic acid concentrations (0.8%, 1.3%, and 1.8%). These formulations were fully characterized in vitro (viscosity, rheologic profiles) and labeled with 99mTc. Their viscosities at 20°C are 54, 60, and 67cP respectively, versus 45cP for Lipiodol ultra-fluide. Second, their biodistribution profiles were studied in vivo, at 24 and 72 hours, in hepatoma-bearing rats, and compared to control group (99mTc-Lipiodol). Biodistribution at 24 hours show a Gaussian tumor uptake profile with a maximum obtained with 1.3% stearic acid, and a tumor uptake superior to control group (+67%) (p<0.05). At 72 hours, optimal tumor uptake is reached with the 0.8% formulation, with 89% increase compared with control group (p<0.05). Moreover, we show a tendency to the decrease of pulmonary uptake for the new formulations at 24 hours and 72 hours. These results suggest a correlation between viscosity and Lipiodol tumor uptake. The new 0.8% stearic acid/Lipiodol formulation appears to be the optimized formulation for Lipiodol treatments of hepatocarcinoma, since it leads to a significant increase of tumor uptake at 72 hours and possibly to a decrease of undesirable pulmonary effects.
File Format	HTM / HTML
ISSN	10849785
Issue Number	2
Volume Number	27
e-ISSN	15578852
Journal	Cancer Biotherapy & Radiopharmaceuticals
Language	English
Publisher	Mary Ann Liebert, Inc.
Publisher Date	2012-03-01
Publisher Place	United States
Access Restriction	Subscribed
Subject Keyword	Discipline Pharmacology Discipline Oncology Ethiodized Oil Chemistry Pharmacokinetics Liver Neoplasms, Experimental Drug Therapy Metabolism Radiopharmaceuticals Animals Antineoplastic Agents Pharmacology Cell Line, Tumor Chemistry, Pharmaceutical Methods Female Lung Rats Rats, Sprague-dawley Stearic Acids Technetium Tissue Distribution Viscosity Journal Article
Content Type	Text
Resource Type	Article
Subject	Radiology, Nuclear Medicine and Imaging Cancer Research Pharmacology Oncology

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