NDLI: si-RNA-Mediated Silencing of ADRBK1 Gene Attenuates Breast Cancer Cell Proliferation.

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si-RNA-Mediated Silencing of ADRBK1 Gene Attenuates Breast Cancer Cell Proliferation.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Zhang, Chen Chen, Xianzhen Li, Yongxin Himaya, S. W. A. Wu, Jie Shi, Xiujuan Liu, Xiaoqing Kim, Sekwon
Description	Country affiliation: China Author Affiliation: Zhang C ( 1 Shanghai Tenth People's Hospital, Tongji University School of Medicine , Shanghai, China .)
Abstract	Abstract Breast cancer is the most prominent cause of cancer-related deaths among women worldwide. It has been found that genetic mutations play distinct roles in the onset and progression of breast cancer. Androgenic, beta, receptor kinase 1 (ADRBK1) has been reported to possess oncogenic characteristics vital for cancer cell viability. This study was designed to investigate the effects of small interference RNA (si-RNA)-mediated ADRBK1 knockdown on breast cancer cell growth in vitro. High-expression levels of ADRBK1 were observed in all tested breast cancer cell lines (MDA-MB-231, MCF-7, T-47D, and BT-474). ADRBK1 si-RNA was delivered to breast cancer cells using lentivirus delivery system. Depletion of ADRBK1 significantly attenuated the cell viability and colony-formation ability. Flow cytometry analysis further demonstrated that ADRBK1 silencing led to MDA-MB-231 cell arrest in the G0/G1 phase. Collectively, these results indicate that knockdown of ADRBK1 gene has detrimental effects on breast cancer cell growth, which may be a potential therapeutic approach for the treatment of breast cancer.
File Format	HTM / HTML
ISSN	10849785
e-ISSN	15578852
DOI	10.1089/cbr.2014.1653
Journal	Cancer Biotherapy & Radiopharmaceuticals
Issue Number	8
Volume Number	29
Language	English
Publisher	Mary Ann Liebert, Inc.
Publisher Date	2014-10-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline Pharmacology Discipline Oncology Breast Neoplasms Therapy G-protein-coupled Receptor Kinase 2 Genetics Rna, Small Interfering Administration & Dosage Apoptosis Enzymology Cell Growth Processes Cell Line, Tumor Deficiency Metabolism Gene Expression Regulation, Neoplastic Gene Knockdown Techniques Gene Silencing Mcf-7 Cells Transfection Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Radiology, Nuclear Medicine and Imaging Cancer Research Pharmacology Oncology

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